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The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review
- Source :
- Human Vaccines & Immunotherapeutics
- Publication Year :
- 2018
- Publisher :
- Taylor & Francis, 2018.
-
Abstract
- Pregnant women are at increased risk of morbidity and mortality from influenza and are recognized as a priority group for influenza vaccination. Despite this, uptake is often poor and one reason cited for this is concerns about safety. The objective of this study was to perform a systematic review of the safety of inactivated influenza vaccination (IIV) in pregnancy. Studies were included if they were: (i) observational or experimental design; (ii) included a comparator group comprising of unvaccinated pregnant women; (iii) comprised of either seasonal IIV or monovalent H1N1 IIV (including adjuvanted vaccines); and (iv) addressed one of the following outcomes: preterm birth (PTB), small for gestational age (SGA), fetal death (including stillbirth or spontaneous abortion), low birth weight (LBW) or congenital abnormalities. Two reviewers screened abstracts and titles and selected full texts for retrieval. Crude odds ratios were calculated from reported event rates, using binomial standard errors. Adjusted odds ratios, hazard ratios and relative rates were extracted as reported in each paper. After removal of duplicates and full text eligibility assessment, 40 studies remained. The aOR for PTB was 0.87 (0.78–0.96), for LBW 0.82 (0.76–0.89), congenital abnormality 1.03 (0.99–1.07), SGA 0.99 (0.94–1.04) and stillbirth 0.84 (0.65–1.08). This study contributes to the increasing body of safety data for IIV in pregnancy and reports a protective effect on PTB and LBW.
- Subjects :
- safety
Adult
medicine.medical_specialty
030231 tropical medicine
Immunology
Abortion
immunization
03 medical and health sciences
0302 clinical medicine
Influenza A Virus, H1N1 Subtype
Pregnancy
Influenza, Human
medicine
Odds Ratio
Immunology and Allergy
Humans
030212 general & internal medicine
reproductive and urinary physiology
Pharmacology
Obstetrics
business.industry
Hazard ratio
Vaccination
Odds ratio
Stillbirth
medicine.disease
Abortion, Spontaneous
Low birth weight
Observational Studies as Topic
Vaccines, Inactivated
Influenza Vaccines
Infant, Small for Gestational Age
Small for gestational age
Premature Birth
Observational study
Female
medicine.symptom
business
influenza
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 2164554X and 21645515
- Volume :
- 15
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Human Vaccines & Immunotherapeutics
- Accession number :
- edsair.doi.dedup.....ea7a2f7be3448614f8cdcf890bc5d47c