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Misophonia is associated with altered brain activity in the auditory cortex and salience network
- Source :
- Scientific reports, 9(1):7542. Nature Publishing Group, Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019), Scientific Reports, Scientific Reports, 9(1). Nature Publishing Group
- Publication Year :
- 2019
-
Abstract
- Misophonia is characterized by intense rage and disgust provoked by hearing specific human sounds resulting in social isolation due to avoidance. We exposed patients with symptom provoking audiovisual stimuli to investigate brain activity of emotional responses. 21 patients with misophonia and 23 matched healthy controls were recruited at the psychiatry department of the Amsterdam UMC. Participants were presented with three different conditions, misophonia related cues (video clips with e.g. lip smacking and loud breathing), aversive cues (violent or disgusting clips from movies), and neutral cues (video clips of e.g. someone meditating) during fMRI. Electrocardiography was recorded to determine physiological changes and self-report measures were used to assess emotional changes. Misophonic cues elicited anger, disgust and sadness in patients compared to controls. Emotional changes were associated with increases in heart rate. The neuroimaging data revealed increased activation of the right insula, right anterior cingulate cortex and right superior temporal cortex during viewing of the misophonic video clips compared to neutral clips. Our results demonstrate that audiovisual stimuli trigger anger and physiological arousal in patients with misophonia, associated with activation of the auditory cortex and salience network.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Brain activity and meditation
media_common.quotation_subject
Emotions
lcsh:Medicine
Audiology
Anger
Auditory cortex
Gyrus Cinguli
Article
Rage
Arousal
03 medical and health sciences
Electrocardiography
0302 clinical medicine
Heart Rate
Surveys and Questionnaires
medicine
Humans
Affective Symptoms
Misophonia
lcsh:Science
media_common
Temporal cortex
Auditory Cortex
Multidisciplinary
lcsh:R
medicine.disease
Magnetic Resonance Imaging
Publisher Correction
Disgust
Temporal Lobe
Sadness
Aggression
Hyperacusis
030104 developmental biology
Female
lcsh:Q
Psychology
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific reports, 9(1):7542. Nature Publishing Group, Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019), Scientific Reports, Scientific Reports, 9(1). Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....ea735fac910e4a3832925b42d6cd3ec8