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MRI Features Associated with Histology of Benign Prostatic Hyperplasia Nodules: Generation of a Predictive Model
- Source :
- J Endourol
- Publication Year :
- 2022
- Publisher :
- Mary Ann Liebert, Inc., publishers, 2022.
-
Abstract
- BACKGROUND: Histologic phenotypic variation of benign prostatic hyperplasia (BPH) has been hypothesized to underlie response to medical therapy. We evaluate preoperative MRI of robot-assisted simple prostatectomy (RASP) specimens and determine imaging features associated with histologic phenotype. MATERIALS AND METHODS: All patients undergoing RASP from November 2015 to November 2019 with a multiparametric MRI ≤1 year before RASP were included. Patients without identifiable BPH nodules on histologic specimens were excluded. Histology slides were obtained from whole mount adenoma specimens and corresponding MRI were reviewed and graded independently by a blinded expert in BPH histopathology (D.W.S.) and an experienced radiologist specializing in prostate imaging (D.N.C.), respectively. Each nodule was assigned a phenotypic score on a 5-point Likert scale (1 = predominantly glandular; 5 = predominantly stromal) by each reviewer. Scores were compared using the sign test and univariate analysis. Signal intensity relative to background transition zone and nodule texture were noted on T2, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging sequences. Univariate and multivariate stepwise linear regression analysis were conducted to identify MRI features associated with histology score. All analyses were performed using Statistical Analysis System (version 9.4). RESULTS: A total of 99 prostate nodules in 29 patients were included. Median phenotypic scores by histology and MRI were comparable (2, interquartile range [IQR] 2–3 vs 2, IQR 2–4, respectively; p = 0.63). Histology scores were positively correlated with MRI scores (Pearson's correlation 0.84, p
- Subjects :
- Male
medicine.medical_specialty
Adenoma
Urology
medicine.medical_treatment
Prostatic Hyperplasia
Prostate
medicine
Humans
Retrospective Studies
Univariate analysis
medicine.diagnostic_test
business.industry
Prostatectomy
Prostatic Neoplasms
Magnetic resonance imaging
Nodule (medicine)
Histology
Imaging and Noninvasive Therapy
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Histopathology
medicine.symptom
business
Nuclear medicine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Endourol
- Accession number :
- edsair.doi.dedup.....ea72df7fc7055209b6d6f55b7edd833b