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Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis

Authors :
Paul, O'Connor
Wolinsky, Jerry S.
Christian, Confavreux
Giancarlo, Comi
Ludwig, Kappos
Olsson, Tomas P.
Hadj, Benzerdjeb
Philippe, Truffinet
Lin, Wang
Aaron, Miller
Temso Trial Group Reingold, Freedman Ms S.
Cutter, G.
Antel, J.
Barkhof, F.
Maddrey, W.
Ravnborg, M.
Schenker, S.
O'Connor, P.
Wolinsky, J. S.
Confavreux, C.
Comi, G.
Kappos, L.
Olsson, T. P.
Miller, A.
Freedman, Mark S.
Narayana, P. A.
Nelson, F.
Vainrub, I.
Datta, S.
He, R.
Gates, B.
Ton, K.
Wamil, B.
Truffinet, P.
Igau, B.
Nicolas, V.
Notelet, L.
Payrard, S.
Wijnand, P.
Devore, S.
H. H., Li
Osho, T.
Wang, L.
Wei, L.
Dukovic, D.
Ling, Y.
Benzerdjeb, H.
Mednikova, Z.
Trabelsi, N.
Musset, M.
Merrill, D.
Turpault, S.
Williams, B.
Nortmeyer, H.
Kirst, E.
Witthaus, E.
Chen, S.
Maida, E.
Auff, E.
Fazekas, F.
Berger, T.
Bhan, V.
Bouchard, J. P.
Duquette, P.
Freedman, M.
Grand'Maison, F.
Kremenchutzky, M.
Bourque, C.
Marrie, R. A.
Melanson, M.
Patry, D.
Oger, J.
Stefanelli, M.
Jacques, F.
Venegas, P.
Miranda, M.
Barrientos, N.
Tenhamm, E.
Gloger, S.
Rohde, G.
Mares, J.
Frederiksen, J.
Stenager, E.
Haldre, S.
Gross Paju, K.
Elovaara, I.
Sumelahti, M. L.
Erälinna, J. P.
Farkkila, M.
Harno, H.
Reunanen, M.
Jolma, T.
Camu, W.
Clavelou, P.
Magy, L.
Debouverie, M.
Edan, G.
Lebrun Frenay, C.
Moreau, T.
Pelletier, J.
Roullet, E.
Alamowitch, S.
Clanet, M.
Hautecoeur, P.
Damier, P.
Rumbach, L.
Chan, A.
Schimrigk, S.
Haas, J.
Lensch, E.
Diener, H.
Limmroth, V.
Anders, D.
Berghoff, M.
Oschmann, P.
Stangel, M.
Frese, A.
Kiefer, R.
Marziniak, M.
Zettl, U.
Stark, E.
Jendroska, K.
Reifschneider, G.
Amato, M. P.
Cosi, V.
Gallo, P.
Gasperini, Claudio
Ghezzi, A.
Trojano, M.
Pozzilli, Carlo
Montanari, E.
Zwanikken, C. P.
Jongen, P. J.
Van Munster, E. T.
Hupperts, R. M.
Anten, B.
Sanders, E. A.
Celius, E.
Hovdal, H.
Krogseth, S. B.
Kozubski, W.
Kwiecinski, H.
Czlonkowska, A.
Stelmasiak, Z.
Selmaj, K.
Hasiec, T.
Fryze, W.
Drozdowski, W.
Kochanowicz, J.
Cunha, L.
De Sa, J.
Sena, A. H.
Odinak, M.
Skoromets, A.
Gusev, E.
Boiko, A.
Lashch, N.
Stolyarov, I.
Belova, A.
Malkova, N.
Doronin, B.
Yakupov, E.
Brundin, L.
Hillert, J.
Karabudak, R.
Irkec, C.
Idiman, E.
Turan, O.
Efendi, H.
Gedizlioglu, M.
Buchakchyyska, N.
Goloborodko, A.
Ipatov, A.
Kobets, S.
Lebedynets, V.
Moskovko, S.
Sanotskyy, Y.
Smolanka, V.
Yavorskaya, V.
Bates, D.
Evangelou, N.
Hawkins, C.
Mclean, B.
O'Riordan, J.
Price, S.
Turner, B.
Barnes, D.
Zajicek, J.
Honeycutt, W.
Khan, O.
Spikol, L.
Stevens, J.
Klinische Neurowetenschappen
RS: MHeNs School for Mental Health and Neuroscience
Source :
Wolinsky, J S, Confavreux, C, Comi, G, Kappos, L, Olsson, T P, Benzerdjeb, H, Truffinet, P, Wang, L, Miller, A E, Freedman, M S, Stenager, E & Teriflunomide Multiple Sclerosis Oral (TEMSO) Trial Group 2011, ' Randomized trial of oral teriflunamide for relapsing multiple sclerosis ', The New England Journal of Medicine, vol. 2011, no. 365, pp. 1293-1303 . https://doi.org/10.1056/NEJMoa1014656, New England Journal of Medicine, 365(14), 1293-1303. MASSACHUSETTS MEDICAL SOCIETY
Publication Year :
2011
Publisher :
Massachusetts Medical Society, 2011.

Abstract

Teriflunomide reduced the annualized relapse rate (0.54 for placebo vs. 0.37 for teri flunomide at either 7 or 14 mg), with relative risk reductions of 31.2% and 31.5%, respectively (P

Subjects

Subjects :
medicine.medical_specialty
biology
Nausea
business.industry
Incidence (epidemiology)
Placebo-controlled study
General Medicine
Placebo
Gastroenterology
Surgery
chemistry.chemical_compound
Alanine transaminase
chemistry
Internal medicine
Relative risk
Teriflunomide
medicine
biology.protein
medicine.symptom
business
Leflunomide
medicine.drug

Details

ISSN :
15334406 and 00284793
Volume :
365
Database :
OpenAIRE
Journal :
New England Journal of Medicine
Accession number :
edsair.doi.dedup.....ea72b10598dc98c42c6663d5f5508b91
Full Text :
https://doi.org/10.1056/nejmoa1014656
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