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A structure–Permeability study of small drug-like molecules
- Source :
- Bioorganic & Medicinal Chemistry Letters. 13:719-722
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- A systematic structure-permeability relationship study on a set of small drug-like molecules with log D values in the range -2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D>0 and
- Subjects :
- Cell Membrane Permeability
Nitrile
Stereochemistry
medicine.drug_class
Carboxylic acid
Clinical Biochemistry
Pharmaceutical Science
Carboxamide
Biochemistry
Cell Line
Amidine
Structure-Activity Relationship
chemistry.chemical_compound
Heterocyclic Compounds
Drug Discovery
medicine
Humans
Molecule
Tetrazole
Molecular Biology
chemistry.chemical_classification
Organic Chemistry
Imidazoles
Partition coefficient
Crystallography
Pyrimidines
chemistry
Molecular Medicine
Benzimidazoles
Efflux
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....ea71bde5dfe4992874fc3ec7d1b60a54