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Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone
- Source :
- PLoS ONE, Vol 11, Iss 6, p e0156130 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Objective To explore the potential damaging effect of chronic pelvic inflammation on ovarian reserve. Design Case-control study. Patients A total of 122 women with bilateral tubal occlusion, diagnosed by hysterosalipingography (HSG) and 217 women with normal fallopians were recruited. Measurements Serum anti-Mullerian hormone (AMH), basic follicle-stimulating hormone (FSH), luteining hormone (LH), estradiol (E2), and testosterone (T) were measured; and antral follicle counts (AFCs) were recorded. Results Significantly lower level of AMH was observed in women with bilateral tubal occlusion compared to control group [2.62 (2.95) ng/ml vs. 3.37 (3.11) ng/ml, P = 0.03], and the difference remained after adjustment of BMI (Padjust = 0.04). However, no statistical difference was found in the levels of FSH [7.00 (2.16) IU/L vs. 6.74 (2.30) IU/L], LH [4.18 (1.52) IU/L vs. 4.63 (2.52) IU/L], E2 [35.95 (20.40) pg/ml vs. 34.90 (17.85) pg/ml], T [25.07±11.46 ng/dl vs. 24.84±12.75 ng/dl], and AFC [6.00 (4.00) vs. 7.00 (4.00)] between two groups (p>0.05). Conclusions Women with bilateral tubal occlusion showed decreased AMH level, suggesting that chronic pelvic inflammation may diminish ovarian reserve. More caution should be paid when evaluating the detriment of PID on female fertility.
- Subjects :
- 0301 basic medicine
Anti-Mullerian Hormone
Peptide Hormones
lcsh:Medicine
Constriction, Pathologic
Primary Ovarian Insufficiency
Pathology and Laboratory Medicine
Biochemistry
Follicle-stimulating hormone
0302 clinical medicine
Risk Factors
Pelvic inflammatory disease
Female Infertility
Medicine and Health Sciences
Testosterone
Ovarian Reserve
lcsh:Science
Immune Response
030219 obstetrics & reproductive medicine
Multidisciplinary
biology
Covariance
Estradiol
Female infertility
Anti-Müllerian hormone
Fallopian Tube Diseases
Physical Sciences
Female
Anatomy
Chronic Pain
Luteinizing hormone
Research Article
Pelvic Inflammatory Disease
Adult
medicine.medical_specialty
Urology
Immunology
Gastroenterology and Hepatology
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Sex Hormones
Humans
Ovarian reserve
Fallopian Tubes
Inflammation
business.industry
Inflammatory Bowel Disease
lcsh:R
Reproductive System
Biology and Life Sciences
Random Variables
Luteinizing Hormone
medicine.disease
Antral follicle
Probability Theory
Hormones
Follicle-Stimulating Hormone
030104 developmental biology
Endocrinology
Infertility
Case-Control Studies
biology.protein
lcsh:Q
Follicle Stimulating Hormone
business
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ea4d617e2f9af5f2e5e52d7a539d0488