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Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
- Source :
- Neurology 79(13), 1332-1339 (2012). doi:10.1212/WNL.0b013e31826c1a8d
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Objective: To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects. Method: [ 18 F]fluoro-2-deoxyglucose PET (FDG-PET) and structural MRI were acquired in 31 subjects with SMI and 56 controls. Cognitive follow-up testing was performed (average follow-up time: 35 months). Differences in baseline brain imaging data and in memory decline were assessed between both groups. Associations of memory decline with brain imaging data were tested. Results: The SMI group showed hypometabolism in the right precuneus and hypermetabolism in the right medial temporal lobe. Gray matter volume was reduced in the right hippocampus in the SMI group. At follow-up, subjects with SMI showed a poorer performance than controls on measures of episodic memory. Longitudinal memory decline in the SMI group was associated with reduced glucose metabolism in the right precuneus at baseline. Conclusion: The cross-sectional difference in 2 independent neuroimaging modalities indicates early AD pathology in SMI. The poorer memory performance at follow-up and the association of reduced longitudinal memory performance with hypometabolism in the precuneus at baseline support the concept of SMI as the earliest manifestation of AD.
- Subjects :
- Male
medicine.medical_specialty
Memory, Episodic
education
Precuneus
physiopathology [Brain]
Neuropsychological Tests
Audiology
Temporal lobe
methods [Magnetic Resonance Imaging]
Neuroimaging
pathology [Brain]
Fluorodeoxyglucose F18
mental disorders
medicine
Humans
ddc:610
Effects of sleep deprivation on cognitive performance
Episodic memory
Aged
Memory Disorders
business.industry
methods [Positron-Emission Tomography]
fungi
Brain
Cognition
medicine.disease
Magnetic Resonance Imaging
metabolism [Glucose]
Glucose
medicine.anatomical_structure
metabolism [Brain]
Positron-Emission Tomography
Hypermetabolism
Female
Neurology (clinical)
diagnosis [Memory Disorders]
Alzheimer's disease
business
Follow-Up Studies
Cognitive psychology
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....ea3fd71ea2c618dc07ae91308dd6c103