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Pesticides used in Europe and autism spectrum disorder risk: can novel exposure hypotheses be formulated beyond organophosphates, organochlorines, pyrethroids and carbamates? - A systematic review
- Source :
- Environmental Research, Environmental Research, Elsevier, 2020, 187, pp.109646. ⟨10.1016/j.envres.2020.109646⟩, Environmental Research, 2020, 187, pp.109646. ⟨10.1016/j.envres.2020.109646⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Background: A growing body of evidences suggests an association between early exposure to organophosphates (OPs), organochlorines (OCs), pyrethroids or carbamates and autism spectrum disorder (ASD). However, there are limited data about the other pesticide groups, especially in Europe. Objectives: Based on a systematic review, we aimed to assess the influence of neuro- and thyrotoxic agricultural and domestic pesticides (other than OPs, OCs, pyrethroids and carbamates) authorized in Europe on risk of ASD in children or ASD behavioral phenotypes in rodents. Methods: Pesticides were initially identified in the Hazardous Substances Data Bank. 20 currently used (10 pesticide groups) were retained based on the higher exposure potential. Epidemiological (children) and in vivo (rodents) studies were identified through PubMed, Web of Science and TOXLINE, without restriction of publication date or country (last update: November 2019). The risk of bias and level of evidence were also assessed. This systematic review is registered at the International Prospective Register of Systematic Reviews (PROSPERO, registration number CRD42019145384). Results: In total, two epidemiological and 15 in vivo studies were retained, focusing on the azole, neonicotinoid, phenylpyrazole and phosphonoglycine pesticide groups. No study was conducted in Europe. Glyphosate, imidacloprid, clothianidin, myclobutanil, acetamiprid, tebuconazole, thiabendazole and fipronil, globally reported an association with an increased risk of ASD in children and/or ASD behavioral phenotypes in rodents. In children, glyphosate and myclobutanil showed a “moderate level of evidence” in their association with ASD, whereas imidacloprid showed an “inadequate level of evidence”. In rodents, clothianidin, imidacloprid and glyphosate showed a “high level of evidence” in their association with altered behavioral, learning and memory skills. Conclusion: In the framework of environmental risk factors of ASD, novel hypotheses can be formulated about early exposure to eight pesticides. Glyphosate presented the most salient level of evidence. Given their neuro- and thyrotoxic properties, additional studies are needed for the 12 other pesticides not yet studied as potential ASD risk factors according to our inclusion criteria.
- Subjects :
- medicine.medical_specialty
010501 environmental sciences
01 natural sciences
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Neurobehavior
0302 clinical medicine
Imidacloprid
Environmental health
Pyrethrins
Epidemiology
medicine
Humans
030212 general & internal medicine
Autism spectrum disorder
Pesticides
Child
0105 earth and related environmental sciences
General Environmental Science
business.industry
Neonicotinoid
Clothianidin
Environmental exposure
Pesticide
medicine.disease
Organophosphates
3. Good health
Europe
Systematic review
chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Carbamates
business
Subjects
Details
- Language :
- English
- ISSN :
- 00139351 and 10960953
- Database :
- OpenAIRE
- Journal :
- Environmental Research, Environmental Research, Elsevier, 2020, 187, pp.109646. ⟨10.1016/j.envres.2020.109646⟩, Environmental Research, 2020, 187, pp.109646. ⟨10.1016/j.envres.2020.109646⟩
- Accession number :
- edsair.doi.dedup.....ea3694e0743aa301a11bd5f892d25bd8