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An analysis of Cyclin D1, Cytokeratin 5/6 and Cytokeratin 8/18 expression in breast papillomas and papillary carcinomas
- Source :
- Diagnostic Pathology, Diagnostic Pathology, Vol 8, Iss 1, p 8 (2013)
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Background To evaluate the expression levels of Cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express Cyclin D1 with Cytokeratin 5/6 (CK 5/6) or with Cytokeratin 8/18(CK 8/18). Methods Fifty-nine cases of papillary lesions including 36 papillomas and 23 intracystic papillary carcinomas were examined. Cyclin D1, CK 5/6 and CK 8/18 expression levels were evaluated by double immunostaining. Results Cyclin D1 is highly expressed in papillary carcinomas (27.54% ± 15.43%) compared with papillomas (8.81% ± 8.41%, p Conclusions The increase in Cyclin D1 suggests an association of Cyclin D1 staining with papillary carcinomas. Although Cyclin D1 is an effective marker for the differential diagnosis of other papillary lesions, it cannot be used to distinguish between papilloma and papillary carcinoma lesions because its expression occurs in both lesions. Our results show that Cyclin D1 and CK 5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 37.00%, CK 5/6 negative). In addition, our data suggest that Cyclin D1 is expressed only in the cancer stem or progenitor cells that co-immunostained with CK 8/18 in papillary carcinomas, and predominantly with CK 8/18 in the papillomas. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7299340558756848
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Histology
Adolescent
Breast Neoplasms
Papillary carcinoma
Biology
Keratin 18
Pathology and Forensic Medicine
Young Adult
Cytokeratin
Cyclin D1
lcsh:Pathology
Biomarkers, Tumor
medicine
Carcinoma
Humans
Double immunostaining
Aged
Keratin-18
Papilloma
Keratin-8
Research
Keratin-6
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Carcinoma, Papillary
Keratin 5
Keratin 8
Keratin-5
Female
lcsh:RB1-214
Subjects
Details
- ISSN :
- 17461596 and 72993405
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Diagnostic Pathology
- Accession number :
- edsair.doi.dedup.....ea0b2ce0cf7329454ab577d5817649ef