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Nuclear cGAS: sequestration and beyond
- Source :
- Protein & Cell
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes, DNA replication forks, the double-stranded breaks, and centromeres, suggesting that cGAS may have other functions in addition to its role in DNA sensing. However, while the innate immune function of cGAS is well established, the non-canonical nuclear function of cGAS remains poorly understood. Here, we review our current understanding of the complex nature of nuclear cGAS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function, beyond its well-established role in dsDNA sensing and innate immune response.
- Subjects :
- nuclear translocation
Regulator
Review
Biochemistry
chemistry.chemical_compound
Interferon
Drug Discovery
medicine
Humans
DNA damage repair
Nucleosome
innate immunity
Cell Nucleus
Innate immune system
DNA replication
Cell Biology
Nucleotidyltransferases
Immunity, Innate
Cell biology
chemistry
micronuclei
Signal transduction
DNA
Function (biology)
Signal Transduction
cGAS
STING
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 16748018 and 1674800X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Protein & Cell
- Accession number :
- edsair.doi.dedup.....e9f160b399eb24eb94fa346e1a42c5cb