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Aberrant epigenetic gene regulation in lymphoid malignancies
- Source :
- Seminars in hematology. 50(1)
- Publication Year :
- 2013
-
Abstract
- In lymphoid malignancies, aberrant epigenetic mechanisms such as DNA methylation and histone modifications influence chromatin architecture and can result in altered gene expression. These alterations commonly affect genes that play important roles in the cell cycle, apoptosis, and DNA repair in non-Hodgkin lymphoma (NHL). The ability to identify epigenetic modifications to these important genes has increased exponentially due to advances in technology. As a result, there are well-defined, gene-specific epigenetic aberrations associated with NHL comprising follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and diffuse large B-cell lymphoma (DLBCL). The identification of these genes is important because they may be used as biomarkers for prognosis, diagnosis and in developing improved treatment strategies. Also important, in the control of gene expression, is the packaging of DNA within the nucleus of a cell. This packaging can be distorted by epigenetic alterations and may alter the accessibility of certain regions of the genome in cancer cells. This review discusses the impact of known epigenetic aberration on the regulation of gene expression in NHL and provides insight into the spatial conformation of the genome (DNA packaging) in acute lymphoblastic leukemia.
- Subjects :
- Regulation of gene expression
Epigenetic regulation of neurogenesis
DNA repair
Lymphoma, Non-Hodgkin
Hematology
DNA
Biology
DNA Methylation
medicine.disease
Chromatin
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Histones
immune system diseases
hemic and lymphatic diseases
DNA methylation
Cancer research
medicine
Animals
Humans
Mantle cell lymphoma
Cancer epigenetics
Epigenetics
Subjects
Details
- ISSN :
- 15328686
- Volume :
- 50
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Seminars in hematology
- Accession number :
- edsair.doi.dedup.....e9f031455503dc8faf081ce69a8e842d