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Onchocercacidal effects of amocarzine (CGP 6140) in Latin America
- Source :
- The Lancet. 337:583-584
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- An open clinical trial of amocarzine was carried out in onchocerciasis patients in Ecuador and Guatemala. Administration after food was more effective than that during fasting. The most effective and best tolerated regimen, 3 mg/kg twice daily after food for 3 days (in 312 patients), killed 73% of 1477 female worms at nodulectomy 4 months after treatment. The mean microfilarial skin count was greatly reduced within a week (6-11% of day 0 value on day 8) and it remained low for at least 6 months (14-18% on day 180). Follow-up of a higher dose 3 day regimen taken while fasting showed microfilaridermia of 7-9% of the day 0 value 2 years after treatment.
- Subjects :
- Adult
medicine.medical_specialty
Amocarzine
medicine.medical_treatment
Helminthiasis
Physiology
Pilot Projects
Onchocerciasis
Drug Administration Schedule
Piperazines
Cohort Studies
medicine
Animals
Humans
Skin
Chemotherapy
business.industry
General Medicine
Guatemala
medicine.disease
Combined Modality Therapy
Surgery
Regimen
Filaricides
Drug Evaluation
Female
Ecuador
Onchocerca
business
After treatment
Follow-Up Studies
Subjects
Details
- ISSN :
- 01406736
- Volume :
- 337
- Database :
- OpenAIRE
- Journal :
- The Lancet
- Accession number :
- edsair.doi.dedup.....e9ef3fae690619ae1c22da269dd804f8