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Reference Intervals for the Markers of Proteinuria with a Standardised Bed-Rest Collection of Urine
- Source :
- Clinical Chemistry and Laboratory Medicine. 39
- Publication Year :
- 2001
- Publisher :
- Walter de Gruyter GmbH, 2001.
-
Abstract
- Reference intervals for markers of proteinuria or glomerular charge selectivity were measured in 61 healthy female and 61 healthy male individuals. Timed bed-rest and daytime collections were used to assess significance of preanalytical variability of results. Bed-rest collections are advisable for research on renal damage, whereas in routine care, robust protein/creatinine ratios work as practical estimates of protein excretion rates, the correlations to excretion rates improving with increasing proteinuria. For glomerular charge selectivity, pancreatic/salivary isoamylase clearance ratio showed lower within-subject biological variation than IgG/IgG4 clearance ratio, allowing more accurate classification into normal and reduced charge selectivity. With our method, the lower 2.5% reference intervals for isoamylase clearance ratio were 1.1 in men and 1.9 in women.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Clinical Biochemistry
Urology
Enzyme-Linked Immunosorbent Assay
Urine
Bed rest
Body Mass Index
Specimen Handling
Excretion
chemistry.chemical_compound
Reference Values
Internal medicine
Acetylglucosaminidase
Alpha-Globulins
medicine
Humans
Isoamylase
Saliva
Creatinine
Proteinuria
business.industry
Biochemistry (medical)
General Medicine
Middle Aged
medicine.disease
Reference intervals
Isoenzymes
Endocrinology
chemistry
Immunoglobulin G
Amylases
Female
medicine.symptom
business
Bed Rest
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 14346621
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry and Laboratory Medicine
- Accession number :
- edsair.doi.dedup.....e9e8842182aa7be25ed0bffc58d56fce