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Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice
- Source :
- Journal of Medicinal Food. 24:431-435
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied. We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS). Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue. The differently prepared sea salts also ameliorated liver injury. In addition, the mineral composition of each salt was different. Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues. However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice. Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
food.ingredient
Colon
Colorectal cancer
Azoxymethane
Medicine (miscellaneous)
Salt (chemistry)
Spleen
Diet, High-Fat
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
food
Internal medicine
Republic of Korea
medicine
Animals
Sodium Chloride, Dietary
chemistry.chemical_classification
Liver injury
030109 nutrition & dietetics
Nutrition and Dietetics
Sea salt
Dextran Sulfate
Cancer
Colitis
medicine.disease
digestive system diseases
Mice, Inbred C57BL
medicine.anatomical_structure
Endocrinology
chemistry
030220 oncology & carcinogenesis
Colonic Neoplasms
Seawater
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 15577600 and 1096620X
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Food
- Accession number :
- edsair.doi.dedup.....e9d5aca7f8b5e493cfc6b0c8e857b448
- Full Text :
- https://doi.org/10.1089/jmf.2020.4836