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Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice

Authors :
Seung Min Lee
Hey-Jin Lee
Eui-Seong Park
Yang-Iee Lim
Ting Yu
Kun-Young Park
Source :
Journal of Medicinal Food. 24:431-435
Publication Year :
2021
Publisher :
Mary Ann Liebert Inc, 2021.

Abstract

The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied. We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS). Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue. The differently prepared sea salts also ameliorated liver injury. In addition, the mineral composition of each salt was different. Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues. However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice. Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.

Details

ISSN :
15577600 and 1096620X
Volume :
24
Database :
OpenAIRE
Journal :
Journal of Medicinal Food
Accession number :
edsair.doi.dedup.....e9d5aca7f8b5e493cfc6b0c8e857b448
Full Text :
https://doi.org/10.1089/jmf.2020.4836