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Comparing the efficacy of Myjet‐assisted tranexamic acid and vitamin C in treating melasma: A split‐face controlled trial
- Source :
- Journal of Cosmetic Dermatology. 19:47-54
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- BACKGROUND Melasma is a benign and chronic hypermelanosis characterized by irregular light brown to dark brown patches of hyperpigmentation on the skin. Oral tranexamic acid (TA) or vitamin C (VC) supplementation has been one treatment choice. TA interferes with keratinocyte-melanocyte interactions, and VC functions by reducing melanin production resulting in skin rejuvenation and whitening. AIM The aim of the present study was to compare the efficacy and safety of Myjet assisted transdermal injection of TA vs VC in the treatment of melasma. METHODS In this split-face controlled trial, 17 patients were randomized to receive eight weekly transdermal injections of TA or VC via Myjet either on the right or the left side of their face. MASI was measured from each side of the face at the baseline, at the middle, and at the end of treatment. RESULTS A reduction in MASI was observed for TA and VC separately (P value
- Subjects :
- Adult
Male
medicine.medical_specialty
Melasma
Injections, Subcutaneous
Skin Pigmentation
Ascorbic Acid
Dermatology
Severity of Illness Index
Melanosis
law.invention
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Image Processing, Computer-Assisted
Photography
medicine
Humans
Effective treatment
Prospective Studies
Adverse effect
Skin
Transdermal
Vitamin C
business.industry
Middle Aged
medicine.disease
Hyperpigmentation
Treatment Outcome
Tranexamic Acid
Patient Satisfaction
Face
030220 oncology & carcinogenesis
Drug Therapy, Combination
Female
medicine.symptom
business
Tranexamic acid
medicine.drug
Subjects
Details
- ISSN :
- 14732165 and 14732130
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Cosmetic Dermatology
- Accession number :
- edsair.doi.dedup.....e9d30c590285d55858e6cbb52590b69d