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The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia
- Source :
- Blood. 131:1755-1758
- Publication Year :
- 2018
- Publisher :
- American Society of Hematology, 2018.
-
Abstract
- TO THE EDITOR: Anergy describes a state of B-cell receptor activation that leads to survival but not to proliferation in chronic lymphocytic leukemia (CLL) cells, and a high proportion of anergic cells correlates with an indolent clinical course. To gain deeper insights into anergic and
- Subjects :
- Male
0301 basic medicine
Chronic lymphocytic leukemia
Immunology
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein tyrosine phosphatase
Biochemistry
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Humans
Medicine
Clonal Anergy
Phosphotyrosine Phosphatase
business.industry
Clinical course
Cell Biology
Hematology
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Neoplasm Proteins
030104 developmental biology
Cancer research
Female
business
Receptor activation
030215 immunology
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....e9b42f4c7faa40de7cde9bfe91d04c03