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Body-Weight Fluctuation and Incident Diabetes Mellitus, Cardiovascular Disease, and Mortality: A 16-Year Prospective Cohort Study
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 104:639-646
- Publication Year :
- 2018
- Publisher :
- The Endocrine Society, 2018.
-
Abstract
- Context Body-weight fluctuation (weight cycling) has been found to be associated with higher mortality and cardiovascular events in patients with coronary artery disease. However, there are very limited data regarding the relationship between body-weight fluctuation and health-related outcomes in the general population. Methods We examined whether body-weight fluctuation can associate incident diabetes mellitus and cardiovascular events, and mortality in a Korean population from the Korean Genome and Epidemiology Study. The intraindividual fluctuations of body weight were calculated by average successive variability (ASV); health-related outcomes were collected every 2 years for 16 years in 3,678 participants. Results Participants with a high ASV of body weight were more obese and had higher blood pressure and HbA1c levels at baseline than those with a low ASV of body weight. A 1-unit increase in ASV of body weight was associated with increase in mortality (HR, 1.46; 95% CI, 1.32 to 1.62; P < 0.001). However, the association between the ASV of body weight and incident diabetes mellitus seemed to be influenced by baseline body mass index (BMI): negative effect in subjects with BMI Conclusion Body-weight fluctuation was associated with mortality. In addition, the effect of body-weight fluctuation on incident diabetes mellitus depended on the presence of obesity at baseline.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Population
030209 endocrinology & metabolism
Context (language use)
Biochemistry
Body Mass Index
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Diabetes mellitus
Republic of Korea
Diabetes Mellitus
Humans
Medicine
Obesity
Prospective Studies
030212 general & internal medicine
education
Prospective cohort study
education.field_of_study
business.industry
Body Weight
Biochemistry (medical)
Middle Aged
medicine.disease
Blood pressure
Cardiovascular Diseases
Female
business
Body mass index
Follow-Up Studies
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....e9b3c71c5d5bf60acce2c9d5967b45ed