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Cytokine and Clinical Predictors for Treatment Outcome of Visually Guided Temporomandibular Joint Irrigation in Patients With Chronic Closed Lock
- Source :
- Journal of Oral and Maxillofacial Surgery. 66:29-34
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- This study investigates selected predictors for clinical outcome of temporomandibular joint (TMJ) irrigation in patients with chronic closed lock (CCL).Fifty-six patients with unilateral CCL, who underwent a visually guided TMJ irrigation (VGIR), were enrolled in this study. They were divided into either successful (s-group; n = 38) or unsuccessful groups (u-group; n = 18), according to the clinical success criteria. The investigated predictive factors were age, gender, duration of symptoms before the VGIR, preoperative painless range of mandibular motion, preoperative self-evaluated TMJ pain on visual analog scale (VAS), severity of arthroscopically observed pathologies, and presence and concentrations of a set of pro- and anti-inflammatory cytokines (ie, tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, IL-6, IL-8, IL-12, and IL-10) in the aspirated synovial fluid (A-SF). Several comparative analyses and logistic regression analyses were used for statistical studies.The preoperative VAS score, detection rate of IL-8, and concentrations of IL-6 and IL-8 in the A-SF were significantly higher in the u-group (P.05). Conversely, the detection rate and concentrations of IL-10 were significantly higher in the s-group (P.05). The multivariate adjusted odds ratio (OR) showed that the detectable IL-10 in the A-SF (OR, 10.882; P = .047) is significantly predictive for a successful VGIR.The presence of IL-10 in the A-SF is a significant predictor of successful outcome of TMJ irrigation for CCL. Severe TMJ pain and detectable IL-6 or IL-8 in the A-SF seem to indicate a poor outcome after TMJ irrigation.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Visual analogue scale
medicine.medical_treatment
Logistic regression
Arthroscopy
Sex Factors
stomatognathic system
Synovial Fluid
Arthropathy
medicine
Humans
Synovial fluid
In patient
Range of Motion, Articular
Therapeutic Irrigation
Temporomandibular Joint
business.industry
Interleukins
Visually guided
Age Factors
Temporomandibular Joint Disorders
medicine.disease
Surgery
Temporomandibular joint
Treatment Outcome
Cytokine
medicine.anatomical_structure
Otorhinolaryngology
Chronic Disease
Female
Oral Surgery
Epidemiologic Methods
business
Subjects
Details
- ISSN :
- 02782391
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Oral and Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....e9b379500220e32b556cd85481c6676c
- Full Text :
- https://doi.org/10.1016/j.joms.2007.06.627