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Superficial vein thrombosis in non-varicose veins of the lower limbs and thrombophilia
- Source :
- Phlebology. 33(4)
- Publication Year :
- 2017
-
Abstract
- Objectives Superficial vein thrombosis in non-varicose veins of the lower limbs is rather frequent and may be underestimated. This study aims to evaluate the prevalence of inherited or acquired thrombophilia in a sample of outpatients with the disease. Method An observational study was conducted on 73 consecutive superficial vein thrombosis patients tested for inherited or acquired thrombophilia. Results Sixty of 73 patients with superficial vein thrombosis completed the testing protocol, while 13 dropped out; 46 of 60 patients were found to have a thrombophilia (76.6%). The types detected were: factor V Leiden (31/60, i.e. 51.6%), prothrombin mutation (2/60, i.e. 3.3%), MTHFR mutation (23/60, i.e. 38.3%), antiphospholipid antibodies (5/60, i.e. 8.3%), protein C deficit (1/60, i.e. 1.6%), protein S deficit (1/60, i.e. 1.6%), and antithrombin deficit (0/60, i.e. 0%). Conclusions Among patients with superficial vein thrombosis in non-varicose veins, testing demonstrated a high prevalence of thrombophilia. The most common form proved to be factor V Leiden. As thrombophilia was found to be a major cause of superficial vein thrombosis in non-varicose veins, the authors recommend that patients with superficial vein thrombosis in non-varicose veins be investigated for thrombophilia.
- Subjects :
- Adult
Male
medicine.medical_specialty
Superficial vein thrombosis
Adolescent
030204 cardiovascular system & hematology
Thrombophilia
Protein S
03 medical and health sciences
0302 clinical medicine
Varicose veins
medicine
Factor V Leiden
Humans
030212 general & internal medicine
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
Aged, 80 and over
Venous Thrombosis
biology
business.industry
Antithrombin
Factor V
General Medicine
Middle Aged
medicine.disease
Surgery
Lower Extremity
Methylenetetrahydrofolate reductase
biology.protein
Antibodies, Antiphospholipid
Female
Prothrombin
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Protein C
medicine.drug
Subjects
Details
- ISSN :
- 17581125
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Phlebology
- Accession number :
- edsair.doi.dedup.....e9ac7cc49fb257a354f969429d289e0b