Back to Search
Start Over
Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats
- Source :
- Biomedical Reports
- Publication Year :
- 2018
- Publisher :
- Spandidos Publications, 2018.
-
Abstract
- Pu-erh tea has become a focus of research due to its reported biological activities, including anti-oxidation, anti-inflammation and anti-immunosenescence. The present study was performed to evaluate the potential gastroprotective function of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats. Sprague Dawley rats were randomly divided into seven groups: A normal control, a model control, a cimetidine (0.08 g/kg) group, three Pu-erh tea extracts groups (low, moderate and high-dose; 0.50, 1.00 and 1.50 g/kg, respectively, and a green tea powder (1.00 g/kg) group. The normal and model groups were pre-treated with distilled water while the other groups were respectively administered cimetidine, Pu-erh tea extracts and green tea powder for 14 days. Then, absolute ethanol was orally administered to the rats of all groups excluding the normal controls. The effects of the pretreatments on gastric mucosal injury were evaluated by gross assessment of gastric lesions, examination of histopathology and determination of myeloperoxidase (MPO) activity and asymmetric arginine (ADMA) concentration in gastric mucosal homogenate. Pre-treatment with cimetidine or Pu-erh tea extracts markedly suppressed the formation of ethanol-induced gastric lesions. Furthermore, clear decreases in MPO activity and ADMA concentration in the gastric mucosal homogenate were observed following pretreatment with cimetidine or Pu-erh tea extracts. The anti-gastric ulcer activity of green tea was less than that of Pu-erh tea. Overall, these effects of Pu-erh tea extracts may be due to potential functions in protecting the gastric mucus layer and suppressing inflammation.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Arginine
Inflammation
Pharmacology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
gastric mucosal damage
asymmetric arginine
General Pharmacology, Toxicology and Pharmaceutics
Cimetidine
Pu-erh tea extracts
Ethanol
biology
Chemistry
General Neuroscience
Articles
General Medicine
rats
myeloperoxidase
030104 developmental biology
Distilled water
Apoptosis
030220 oncology & carcinogenesis
Myeloperoxidase
biology.protein
Histopathology
medicine.symptom
medicine.drug
Subjects
Details
- ISSN :
- 20499442 and 20499434
- Database :
- OpenAIRE
- Journal :
- Biomedical Reports
- Accession number :
- edsair.doi.dedup.....e9a6ad96007fadced0369f923aa4c944