Back to Search
Start Over
Gout: an independent risk factor for all-cause and cardiovascular mortality
- Source :
- Rheumatology (Oxford, England). 49(1)
- Publication Year :
- 2009
-
Abstract
- The relation of gout and hyperuricaemia to cardiovascular diseases has been well documented. This study investigates the survival impact of both gout and hyperuricaemia.The subjects of this study comprised participants of a health screening programme conducted by the Chang Gung Memorial Hospital in Taiwan from 2000 to 2006. The status and causes of death were ascertained by the Taiwan National Death Registry 2000-07. Cox proportional hazard model was performed to examine the association.Among 61 527 subjects, 1383 deaths (198 cardiovascular deaths) were identified, corresponding to a crude mortality rate of 4.86 deaths per 1000 person-years. Crude mortality rates were 4.50, 5.61 and 10.46 deaths per 1000 person-years for subjects with normouricaemia, hyperuricaemia and gout, respectively. Compared with subjects with normouricaemia, the hazard ratios (HRs) of all-cause mortality were 1.46 (95% CI 1.12, 1.91) for individuals with gout and 1.07 (95% CI 0.94, 1.22) for those with hyperuricaemia, respectively, after adjustments were made for age, sex, component number of metabolic syndrome and proteinuria. The adjusted HRs of cardiovascular mortality were 1.97 (95% CI 1.08, 3.59) for individuals with gout and 1.08 (95% CI 0.78, 1.51) for those with hyperuricaemia. Moreover, the risk of all-cause or cardiovascular mortality for gout remained unchanged when limiting the data to those with an estimated glomerular filtration of60 ml/min/1.73 m(2).This study demonstrates a link of gout, not hyperuricaemia, with a higher risk of death from all causes and cardiovascular diseases.
- Subjects :
- musculoskeletal diseases
Adult
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Gout
Taiwan
Hyperuricemia
chemistry.chemical_compound
Rheumatology
Internal medicine
medicine
Humans
Pharmacology (medical)
Risk factor
Cause of death
Aged
Proportional hazards model
business.industry
Mortality rate
Hazard ratio
nutritional and metabolic diseases
Middle Aged
medicine.disease
Surgery
chemistry
Cardiovascular Diseases
Uric acid
Female
business
Epidemiologic Methods
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14620332
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Rheumatology (Oxford, England)
- Accession number :
- edsair.doi.dedup.....e99e02cf43054d0c2730515834e34bd7