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Age-specific reference values for carotid arterial stiffness estimated by ultrasonic wall tracking
- Source :
- Journal of Human Hypertension
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Interaction between arterial stiffness and hypertension plays an important role in the development of cardiovascular disease. Accordingly, assessment of arterial stiffness may provide a tool for estimating cardiovascular risk and monitoring therapy in hypertensive patients. Radiofrequency-based vascular ultrasound allows accurate noninvasive assessment of local mechanical properties of large arteries, but for its use in clinical practice, reference values according to age and sex are mandatory for each vascular site. To provide reference values for common carotid artery stiffness as assessed by an echo-tracking imaging system Hitachi-Aloka, we pooled measurements collected in 1847 healthy subjects aged 3–74 years (1008 males and 839 females) recruited in 14 European centers in the E-tracking International Collaboration (ETIC). Statistical models were developed to describe relationships of different stiffness indices with age and to calculate median values and Z-scores corresponding to ± 1 and ± 2 standard deviations. In our apparently healthy population, age accounted for 53% of variability in the elastic modulus (epsilon), 39% in arterial compliance, 47% in stiffness index (β), and 56% in local pulse wave velocity; on average, blood pressure accounted for a further 7.5% of variability. Dependence on age was not linear; changes in mean values increased at older ages, especially for epsilon and β. There was an interaction between age and gender for arterial compliance, which was higher in males. We present nomograms and a software that can be used for the automated calculation of Z-scores for local carotid stiffness in individual patients. These tools can be used to establish prognostic indicators or surrogate targets for treatment monitoring.
- Subjects :
- Male
cardiovascular risk
medicine.medical_specialty
normal reference values
Pulse Wave Analysis
030204 cardiovascular system & hematology
Article
Standard deviation
03 medical and health sciences
Vascular Stiffness
0302 clinical medicine
vascular age
Reference Values
Internal medicine
medicine.artery
Internal Medicine
medicine
Humans
Ultrasonics
Common carotid artery
Pulse wave velocity
Aged
Ultrasonography
ultrasound
business.industry
Age Factors
Correction
Stiffness
Middle Aged
Nomogram
medicine.disease
Compliance (physiology)
Carotid Arteries
Carotid stiffness, normal reference values, vascular age, cardiovascular risk, ultrasound
Blood pressure
Risk factors
Carotid stiffness
Cardiology
Arterial stiffness
Female
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14765527 and 09509240
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Human Hypertension
- Accession number :
- edsair.doi.dedup.....e9761d06cffe195dbf77a678eac9287a