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The clinical use of regenerative therapy in COPD
- Source :
- International Journal of Chronic Obstructive Pulmonary Disease, International Journal of COPD, Vol 2014, Iss default, Pp 1389-1396 (2014)
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- Roberto Lipsi,1 Paola Rogliani,1 Luigino Calzetta,2 Andrea Segreti,1Mario Cazzola1 1Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Pulmonary Rehabilitation, San Raffaele Pisana Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Rome, Italy Abstract: Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues. Current evidence suggests that in the lung, these cells may participate in tissue homeostasis and regeneration after injury. Animal and human studies have demonstrated that tissue-specific stem cells and bone marrow-derived cells contribute to lung tissue regeneration and protection, and thus administration of exogenous stem/progenitor cells or humoral factors responsible for the activation of endogenous stem/progenitor cells may be a potent next-generation therapy for chronic obstructive pulmonary disease. The use of bone marrow-derived stem cells could allow repairing and regenerate the damaged tissue present in chronic obstructive pulmonary disease by means of their engraftment into the lung. Another approach could be the stimulation of resident stem cells by means of humoral factors or photobiostimulation. Keywords: chronic obstructive pulmonary disease, stem cells, regenerative therapy, all-trans retinoic acid, photobiostimulation
- Subjects :
- Chronic Obstructive
Pathology
medicine.medical_specialty
Settore MED/10 - Malattie dell'Apparato Respiratorio
medicine.medical_treatment
Review
Regenerative Medicine
Regenerative medicine
chronic obstructive pulmonary disease
Pulmonary Disease
Pulmonary Disease, Chronic Obstructive
stem cells
Animals
Humans
Regeneration
Medicine
photobiostimulation
all-trans retinoic acid
regenerative therapy
Laser Therapy, Low-Level
Lung
Recovery of Function
Treatment Outcome
Stem Cell Transplantation
Low-Level Light Therapy
Progenitor cell
Tissue homeostasis
lcsh:RC705-779
COPD
business.industry
Regeneration (biology)
lcsh:Diseases of the respiratory system
General Medicine
Stem-cell therapy
medicine.disease
medicine.anatomical_structure
Low-Level
Cancer research
Laser Therapy
Stem cell
business
Subjects
Details
- ISSN :
- 11782005
- Database :
- OpenAIRE
- Journal :
- International Journal of Chronic Obstructive Pulmonary Disease
- Accession number :
- edsair.doi.dedup.....e9738e5bd17cbf2a10158e50c85fb0e1