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Coenzyme Q_{10} effects on manganese superoxide dismutase and glutathione peroxidase in the hairless mouse skin induced by ultraviolet B irradiation
- Source :
- BioFactors (Oxford, England). 30(3)
- Publication Year :
- 2008
-
Abstract
- Coenzyme Q_{10} (CoQ_{10}) is a naturally occurring antioxidant and a prominent component of mitochondrial electron transport chain. In the present study, we investigated the effect of CoQ_{10} nanoparticle against photoaging using immunohistochemistry and Western blot analysis in the hairless mouse skin induced by ultraviolet B (UVB) irradiation (300 mJ/cm;{2}, 3 min/day for 21 days). In the UVB-irradiated distilled water (DW)-treated group, manganese superoxide dismutase (SOD2) and glutathione peroxidase (GPx) immunoreactivity and their protein levels in the skin were significantly lower than those in the control group. However, SOD2 and GPx immunoreactivity and their protein levels in the skin of the UVB-irradiated CoQ_{10}-treated group were higher than those in the UVB-irradiated DW-treated group. GPx activity in the skin in the UVB-irradiated DW-treated group significantly decreased compared to that in the control group; whereas GPx activity in the UVB-irradiated CoQ_{10}-treated group was similar to that in the control group. These results suggest that CoQ_{10} strongly inhibits oxidative stress in the skin induced by UVB via increasing SOD2 and GPx.
- Subjects :
- Antioxidant
Ubiquinone
Ultraviolet Rays
medicine.medical_treatment
Photoaging
Clinical Biochemistry
Blotting, Western
SOD2
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
Mice
Random Allocation
medicine
Animals
skin and connective tissue diseases
Skin
chemistry.chemical_classification
Coenzyme Q10
Glutathione Peroxidase
Mice, Hairless
integumentary system
Superoxide Dismutase
Glutathione peroxidase
General Medicine
medicine.disease
Molecular biology
Immunohistochemistry
Hairless
Enzyme Activation
chemistry
Coenzyme Q – cytochrome c reductase
Molecular Medicine
Female
Oxidative stress
Subjects
Details
- ISSN :
- 09516433
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- BioFactors (Oxford, England)
- Accession number :
- edsair.doi.dedup.....e9661aa812a299e44e51859d9a5f164f