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Inhibitory effects of gangliosides on immune reactions of antibodies to neutral glycolipids in liposomes
- Source :
- Biochimica et biophysica acta. 858(1)
- Publication Year :
- 1986
-
Abstract
- Specific immune damage to liposomes containing Forssman or globoside glycolipid was inhibited when the liposomes also contained ganglioside. The activity of a human monoclonal Waldenstrom macroglobulin antibody to Forssman glycolipid was inhibited by each of three gangliosides tested, G M3 , G D1a and G D1b . Inhibition of the monoclonal antibody was dependent on the amount of ganglioside in the liposomes, and was diminished by reducing the relative amount of ganglioside. Inhibition also correlated positively with the number of ganglioside sialic acid groups, with inhibition by G T1b > G D1a > G M3 . Naturally occurring human antibodies to globoside glycolipid were detected in 18% (9 out of 50) of normal human sera tested. Immune damage to liposomes induced by each of the three highest-reacting human anti-globoside sera was blocked by liposomal G M3 . We conclude that gangliosides can strongly influence immune damage to membranes induced by antibody interactions with adjacent neutral glycolipids.
- Subjects :
- medicine.drug_class
Biophysics
In Vitro Techniques
Monoclonal antibody
Biochemistry
Antigen-Antibody Reactions
chemistry.chemical_compound
Glycolipid
Gangliosides
medicine
Humans
Complement Activation
Forssman Antigen
Liposome
Ganglioside
Globoside
biology
Globosides
Temperature
Antibodies, Monoclonal
Cell Biology
Sialic acid
Macroglobulin
chemistry
Liposomes
biology.protein
Antibody
Glycolipids
Subjects
Details
- ISSN :
- 00063002
- Volume :
- 858
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta
- Accession number :
- edsair.doi.dedup.....e9553f99024a1eace56fb96c703f7465