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Identification of Cinnamaldehyde as Most Effective Fatty Acid Uptake Reducing Cinnamon-Derived Compound in Differentiated Caco-2 Cells Compared to Its Structural Analogues Cinnamyl Alcohol, Cinnamic Acid, and Cinnamyl Isobutyrate
- Source :
- Journal of agricultural and food chemistry. 67(42)
- Publication Year :
- 2019
-
Abstract
- Naturally occurring cinnamon compounds such as cinnamaldehyde (CAL) and structurally related constituents have been associated with antiobesity activities, although studies regarding the impact on intestinal fatty acid uptake are scarce. Here, we demonstrate the effects of CAL and structural analogues cinnamyl alcohol (CALC), cinnamic acid (CAC), and cinnamyl isobutyrate on mechanisms regulating intestinal fatty acid uptake in differentiated Caco-2 cells. CAL, CALC, and CAC (3000 μM) were found to decrease fatty acid uptake by 58.0 ± 8.83, 19.4 ± 8.98, and 21.9 ± 6.55%, respectively. While CAL and CALC at a concentration of 300 μM increased serotonin release 14.9 ± 3.00- and 2.72 ± 0.69-fold, respectively, serotonin alone showed no effect on fatty acid uptake. However, CAL revealed transient receptor potential channel A1-dependency in the decrease of fatty acid uptake, as well as in CAL-induced serotonin release. Overall, CAL was identified as the most potent of the cinnamon constituents tested.
- Subjects :
- Cinnamomum zeylanicum
Propanols
Cinnamic acid
Cinnamaldehyde
Transient receptor potential channel
chemistry.chemical_compound
Humans
Acrolein
Intestinal Mucosa
chemistry.chemical_classification
Cinnamyl alcohol
Chemistry
Plant Extracts
Fatty Acids
Fatty acid
Biological Transport
Cell Differentiation
General Chemistry
humanities
stomatognathic diseases
Biochemistry
Caco-2
Cinnamates
Serotonin
Caco-2 Cells
General Agricultural and Biological Sciences
Cinnamyl isobutyrate
Subjects
Details
- ISSN :
- 15205118
- Volume :
- 67
- Issue :
- 42
- Database :
- OpenAIRE
- Journal :
- Journal of agricultural and food chemistry
- Accession number :
- edsair.doi.dedup.....e94afe8520f3d5ca83dd97b040ed7507