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Comparative Analysis of Adverse Events From a Series of Proof-of-Principle Extended Wear Studies
- Source :
- Eyecontact lens. 45(2)
- Publication Year :
- 2018
-
Abstract
- AIM A series of proof-of-principle extended wear (EW) contact lens studies were conducted to assess what effect different interventions had on adverse events (AEs). Comparative analysis of AEs across studies was conducted to determine whether some interventions were more effective at reducing inflammatory AEs. METHOD Multiple logistic regression analysis of AEs from 30-day EW studies each with a different intervention including (1) nightly replacement (NR) of lenses, (2) morning replacement (MR) of lenses, (3) instillation of prophylactic antibiotic drops (AB) each morning/evening, (4) daily lens cleaning (LC) each morning. All studies conducted at the same site using same lens type (lotrafilcon A) and EW schedule. RESULTS Comparison of the different interventions to the individual control groups showed no difference in significant corneal infiltrative event (CIE) or mechanical events. Replacing lenses nightly, during an EW schedule, had the highest incidence of significant CIEs (4.9% [NR] vs. 2.5% [MR] vs. 1.8% [AB] vs. 0% [LC]); however, adjusted logistic regression analysis of the combined control data compared with the individual interventions showed no difference in significant CIEs (P=0.086) or mechanical AEs (P=0.140). CONCLUSIONS Replacing lenses each night seemed to be inferior compared with the other interventions of replacing lenses each morning, daily lens cleaning, and daily antibiotic drop instillation during EW. The results of the collective studies and additional analysis suggest that overnight wear of contact lenses seems to create an adverse environment that remains, despite the various interventions intended to improve this adverse environment.
- Subjects :
- Male
medicine.medical_specialty
Evening
Extended wear
Logistic regression
Eye Infections, Bacterial
03 medical and health sciences
Young Adult
0302 clinical medicine
Control data
Internal medicine
Medicine
Humans
Prospective Studies
Adverse effect
Disposable Equipment
Morning
business.industry
Incidence (epidemiology)
Incidence
Anti-Bacterial Agents
Contact lens
Ophthalmology
030221 ophthalmology & optometry
Contact Lenses, Extended-Wear
Female
Ophthalmic Solutions
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 1542233X
- Volume :
- 45
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Eyecontact lens
- Accession number :
- edsair.doi.dedup.....e93ffe5d9a16c425b7871fcb39014f94