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Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study
- Source :
- Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015), Evidence-based Complementary and Alternative Medicine : eCAM
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- We aimed to compare effectiveness of Wenxin Keli (WK) and sotalol in assisting sinus rhythm (SR) restoration from paroxysmal atrial fibrillation (PAF) caused by hyperthyroidism, as well as in maintaining SR. We randomly prescribed WK (18 g tid) or sotalol (80 mg bid) to 91 or 89 patients. Since it was not ethical not to give patients antiarrhythmia drugs, no control group was set. Antithyroid drugs were given to 90 patients (45 in WK group, 45 in sotalol group);131I was given to 90 patients (46 in WK group, 44 in sotalol group). Three months later, SR was obtained in 83/91 or 80/89 cases from WK or sotalol groups(P=0.762). By another analysis, SR was obtained in 86/90 or 77/90 cases from131I or ATD groups(P=0.022). Then, we randomly assigned the successfully SR-reverted patients into three groups: WK, sotalol, and control (no antiarrhythmia drug was given) groups. After twelve-month follow-up, PAF recurrence happened in 1/54, 2/54, and 9/55 cases, respectively. Log-Rank test showed significant higher PAF recurrent rate in control patients than either treatment(P=0.06). We demonstrated the same efficacies of WK and sotalol to assist SR reversion from hyperthyroidism-caused PAF. We also showed that either drug could maintain SR in such patients.
- Subjects :
- medicine.medical_specialty
Article Subject
Antithyroid drugs
Paroxysmal atrial fibrillation
business.industry
Sotalol
lcsh:Other systems of medicine
lcsh:RZ201-999
law.invention
Surgery
Complementary and alternative medicine
Randomized controlled trial
law
Antiarrhythmia drugs
Anesthesia
medicine
Sinus rhythm
Wenxin keli
Open label
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....e93909de76f87fd6c108c49d7021ad28