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Combination therapy of an intestine-specific inhibitor of microsomal triglyceride transfer protein and peroxisome proliferator-activated receptor γ agonist in diabetic rat
- Source :
- Journal of Diabetes Research, Journal of Diabetes Research, Vol 2014 (2014)
- Publication Year :
- 2014
-
Abstract
- We investigated effects on glucose and lipid metabolism in combination of JTT-130, a novel intestine-specific microsomal triglyceride transfer protein (MTP) inhibitor, and pioglitazone, peroxisome proliferator-activated receptor (PPAR)γagonist. Male Zucker diabetic fatty rats were divided into 4 groups: control group, JTT-130 treatment group, pioglitazone treatment group, and combination group. The Zucker diabetic fatty rats were fed a regular powdered diet with JTT-130 and/or pioglitazone as a food admixture for 6 weeks. Effects on glucose and lipid metabolism were compared mainly between JTT-130 treatment group and combination group. JTT-130 treatment showed good glycemic control, while the plasma glucose and glycated hemoglobin levels in combination group were significantly decreased as compared with those JTT-130 treatment group. The reduction in the plasma triglyceride and free fatty acid levels in combination group was higher than that in JTT-130 treatment group, and glucose utilization was significantly elevated in adipose tissues. In Zucker diabetic fatty rats, combination treatment of JTT-130 and pioglitazone showed better glycemic control and a strong hypolipidemic action with an enhancement of insulin sensitivity. Combination therapy of MTP inhibitor and PPARγagonist might be more useful in the treatment of type 2 diabetes accompanied with obesity and insulin resistance.
- Subjects :
- Agonist
Male
medicine.medical_specialty
Article Subject
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Adipose Tissue, White
Peroxisome proliferator-activated receptor
Hyperlipidemias
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Microsomal triglyceride transfer protein
chemistry.chemical_compound
Endocrinology
Insulin resistance
Gastrointestinal Agents
Internal medicine
medicine
Animals
Hypoglycemic Agents
Obesity
Hypolipidemic Agents
chemistry.chemical_classification
Glycated Hemoglobin
lcsh:RC648-665
biology
Pioglitazone
Chemistry
Fatty acid
Lipid metabolism
medicine.disease
Lipids
Malonates
Rats
Rats, Zucker
PPAR gamma
Diabetes Mellitus, Type 2
Hyperglycemia
Benzamides
biology.protein
Drug Therapy, Combination
Thiazolidinediones
Glycated hemoglobin
Insulin Resistance
Carrier Proteins
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 23146753
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Journal of diabetes research
- Accession number :
- edsair.doi.dedup.....e9306984bea9e1ffeddb94526e778675