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Temporal response of biochemical and biological sensors with bimodal surface adsorption from a finite sample
- Source :
- Microsystem Technologies
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The importance of adsorption-based biochemical/biological sensors in biochemistry and biophysics is paramount. Their temporal response gives information about the presence of a biochemical/biological analyte, its concentration and its interactions with the adsorption sites (which may be an integral part of the surface itself or immobilized functionalizing molecules). Mathematical models of the temporal response taking into account as many relevant effects as possible are essential for obtaining reliable information. We present a novel model taking into account the bimodal affinity of a sensing surface (adsorption occurs on two distinct site types), and the adsorption-caused depletion of the analyte from the sample. We perform qualitative and quantitative analysis of the analyte depletion influence on the bimodal adsorption, and of the influence of the sensing surface inhomogeneity on the sensor temporal response, for different analyte concentrations and different fractions of two types of adsorption sites. Since the presented mathematical model deals with the realistic cases of the sensing surface non-uniformity and the finite amount of analyte present in the sensor reaction chamber, it enables improved accuracy in interpreting the measurement data. Our results are general, i.e. valid for any adsorption sensor (microcantilevers, plasmonics) and for arbitrary sensor dimensions.
- Subjects :
- biochemical/biological sensors
Surface (mathematics)
Analyte
Materials science
analyte depletion
02 engineering and technology
01 natural sciences
Adsorption
0103 physical sciences
Molecule
Electrical and Electronic Engineering
Reaction chamber
bimodal affinity
Plasmon
010302 applied physics
Mathematical models
Mathematical model
Technical Paper
021001 nanoscience & nanotechnology
Condensed Matter Physics
Sample (graphics)
Electronic, Optical and Magnetic Materials
adsorption
Hardware and Architecture
0210 nano-technology
Biological system
Subjects
Details
- ISSN :
- 14321858 and 09467076
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Microsystem Technologies
- Accession number :
- edsair.doi.dedup.....e92f7ef9de653fe35922b5b53203c7c2