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The importance of the gastrointestinal system in the pathogenesis of heart failure
- Source :
- European Heart Journal. 26:2368-2374
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- Chronic heart failure (CHF) is a multi-organ disease with increasing evidence for the involvement of the gastrointestinal (GI) system in this syndrome. In recent research, the gut has received very little attention from cardiologists as its role in the pathogenesis of cardiovascular disease is poorly understood. Intestinal ischaemia may play an important role in bacterial translocation by increasing bowel permeability. Decreased cardiac function can reduce bowel perfusion and so clearly impairs the function of the intestinal barrier. There is an increasing evidence to suggest that a 'leaky' bowel wall may lead to translocation of bacteria and/or endotoxin, which may be an important stimulus for inflammatory cytokine activation in CHF. Impaired functioning of the GI system may also contribute to malnutrition and cachexia in CHF. It is hoped that by improving our understanding of the role of the gut in cardiac disease will lead to the development of novel therapeutic strategies in the future.
- Subjects :
- Cardiac function curve
medicine.medical_specialty
Heart disease
Gastrointestinal Diseases
Inflammation
Disease
Bioinformatics
Cachexia
Pathogenesis
Internal medicine
medicine
Humans
Exercise
Heart Failure
business.industry
medicine.disease
Endotoxins
Gastrointestinal Tract
Endocrinology
Bacterial Translocation
Heart failure
Chronic Disease
Circulatory system
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Forecasting
Subjects
Details
- ISSN :
- 15229645 and 0195668X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- European Heart Journal
- Accession number :
- edsair.doi.dedup.....e92bf75402f4b53ed6d9266987b03ea0