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Temporal control of neural crest lineage generation by Wnt/ß-catenin signaling
- Source :
- Development (Cambridge England)
- Publication Year :
- 2012
-
Abstract
- Wnt/β-catenin signaling controls multiple steps of neural crest development, ranging from neural crest induction, lineage decisions, to differentiation. In mice, conditional β-catenin inactivation in premigratory neural crest cells abolishes both sensory neuron and melanocyte formation. Intriguingly, the generation of melanocytes is also prevented by activation of β-catenin in the premigratory neural crest, which promotes sensory neurogenesis at the expense of other neural crest derivatives. This raises the question of how Wnt/β-catenin signaling regulates the formation of distinct lineages from the neural crest. Using various Cre lines to conditionally activate β-catenin in neural crest cells at different developmental stages, we show that neural crest cell fate decisions in vivo are subject to temporal control by Wnt/β-catenin. Unlike in premigratory neural crest, β-catenin activation in migratory neural crest cells promotes the formation of ectopic melanoblasts, while the production of most other lineages is suppressed. Ectopic melanoblasts emerge at sites of neural crest target structures and in many tissues usually devoid of neural crest-derived cells. β-catenin activation at later stages in glial progenitors or in melanoblasts does not lead to surplus melanoblasts, indicating a narrow time window of Wnt/β-catenin responsiveness during neural crest cell migration. Thus, neural crest cells appear to be multipotent in vivo both before and after emigration from the neural tube but adapt their response to extracellular signals in a temporally controlled manner.
- Subjects :
- Doublecortin Domain Proteins
Time Factors
animal structures
Biology
SOXE Transcription Factors
03 medical and health sciences
Mice
0302 clinical medicine
Cell Movement
medicine
Animals
Cell Lineage
Molecular Biology
Wnt Signaling Pathway
beta Catenin
030304 developmental biology
Body Patterning
Neurons
0303 health sciences
Neural fold
Microphthalmia-Associated Transcription Factor
Ganglia, Sympathetic
Integrases
Stem Cells
Neurogenesis
Neuropeptides
Wnt signaling pathway
Neural tube
Neural crest
Embryo, Mammalian
Immunohistochemistry
Cell biology
medicine.anatomical_structure
Neural Crest
Immunology
Attachment Sites, Microbiological
embryonic structures
Melanocytes
Neural crest cell migration
Neural plate
Microtubule-Associated Proteins
030217 neurology & neurosurgery
Biomarkers
Developmental Biology
Subjects
Details
- Volume :
- 139
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Development (Cambridge England)
- Accession number :
- edsair.doi.dedup.....e92b8627ad2f33d455d6c92f2b1c2e0b
- Full Text :
- https://doi.org/10.1242/dev.073064