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Urinary concentrations of cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester, a metabolite of the non-phthalate plasticizer di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), and markers of ovarian response among women attending a fertility center
- Source :
- Environmental Research. 151:595-600
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), a non-phthalate plasticizer, was introduced commercially in 2002 as an alternative to ortho-phthalate esters because of its favorable toxicological profile. However, the potential health effects from DINCH exposure remain largely unknown. We explored the associations between urinary concentrations of metabolites of DINCH on markers of ovarian response among women undergoing in vitro fertilization (IVF) treatments. Between 2011 and 2015, 113 women enrolled a prospective cohort study at the Massachusetts General Hospital Fertility Center and provided up to two urine samples prior to oocyte retrieval. The urinary concentrations of two DINCH metabolites, cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester (MHiNCH) and cyclohexane-1,2-dicarboxylic acid monocarboxyisooctyl ester (MCOCH), were quantified by isotope dilution tandem mass spectrometry. We used generalized linear mixed models to evaluate the association between urinary metabolite concentrations and markers of ovarian response, accounting for multiple IVF cycles per woman via random intercepts. On average, women with detectable urinary MHiNCH concentrations, as compared to those below LOD, had a lower estradiol levels (-325 pmol/l, p=0.09) and number of retrieved oocytes (-1.8, p=0.08), with a stronger association among older women. However, urinary MHiNCH concentrations were unrelated to mature oocyte yield and endometrial wall thickness. In conclusion, we found suggestive negative associations between urinary MHiNCH concentrations and peak estradiol levels and number of total oocyte yields. This is the first study evaluating the effect of DINCH exposure on human reproductive health and raises the need for further experimental and epidemiological studies to better understand the potential effects of this chemical on health.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
Adolescent
Cyclohexanecarboxylic Acids
Urinary system
medicine.medical_treatment
Metabolite
Oocyte Retrieval
Fertilization in Vitro
Urine
010501 environmental sciences
Endometrium
01 natural sciences
Biochemistry
Article
Young Adult
03 medical and health sciences
chemistry.chemical_compound
Ovulation Induction
Plasticizers
Internal medicine
medicine
Humans
Dicarboxylic Acids
Prospective Studies
Prospective cohort study
0105 earth and related environmental sciences
General Environmental Science
In vitro fertilisation
Chemistry
Age Factors
Phthalate
Middle Aged
Reproductive Health
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Oocytes
Female
Ovulation induction
Biomarkers
Maternal Age
Subjects
Details
- ISSN :
- 00139351
- Volume :
- 151
- Database :
- OpenAIRE
- Journal :
- Environmental Research
- Accession number :
- edsair.doi.dedup.....e920c6238cafa431ffebee95c80cf714