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Toxoplasmic Encephalitis in an AIDS Cohort at Puerto Rico before and after Highly Active Antiretroviral Therapy (HAART)
- Publication Year :
- 2011
- Publisher :
- The American Society of Tropical Medicine and Hygiene, 2011.
-
Abstract
- Highly active antiretroviral therapy (HAART) significantly reduced the toxoplasmic encephalitis (TE) incidence in acquired immunodeficiency syndrome (AIDS) patients. The TE incidence and mortality were evaluated in an AIDS cohort followed in Puerto Rico before, during, and after HAART implementation in the Island. Of the 2,431 AIDS studied patients 10.9% had TE diagnosis, with an incidence density that decreased from 5.9/100 person-years to 1.1/100 person-years after HAART. Cox proportional hazard analysis showed substantial mortality reduction among TE cases who received HAART. No mortality reduction was seen in those cases who received TE prophylaxis. Although this study shows a TE incidence and mortality reduction in the AIDS cohort after HAART, the incidence was higher than those reported in the United States AIDS patients. Poor TE prophylaxis compliance might explain the lack of impact of this intervention. Strengthening the diagnostic and opportune TE diagnosis and prompt initiation of HAART in susceptible patients is important to control this opportunistic infection.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Opportunistic infection
AIDS-Related Opportunistic Infections
Cohort Studies
Acquired immunodeficiency syndrome (AIDS)
Virology
Antiretroviral Therapy, Highly Active
medicine
Humans
Sida
Acquired Immunodeficiency Syndrome
biology
business.industry
Incidence (epidemiology)
Puerto Rico
Articles
medicine.disease
biology.organism_classification
Surgery
Infectious Diseases
Toxoplasmosis, Cerebral
Cohort
Patient Compliance
Parasitology
Female
Viral disease
business
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e911302961401cf8d652d1b3c3f2f0b6