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Robustness and relevance of predictive score in sudden cardiac death for patients with Brugada syndrome
- Source :
- European Heart Journal. 42:1687-1695
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Aims Risk stratification of sudden cardiac arrest (SCA) in Brugada syndrome (Brs) remains the main challenge for physicians. Several scores have been suggested to improve risk stratification but never replicated. We aim to investigate the accuracy of the Brs risk scores. Methods and results A total of 1613 patients [mean age 45 ± 15 years, 69% male, 323 (20%) symptomatic] were prospectively enrolled from 1993 to 2016 in a multicentric database. All data described in the risk score were double reviewed for the study. Among them, all patients were evaluated with Shanghai score and 461 (29%) with Sieira score. After a mean follow-up of 6.5 ± 4.7 years, an arrhythmic event occurred in 75 (5%) patients including 16 SCA, 11 symptomatic ventricular arrhythmia, and 48 appropriate therapies. Predictive capacity of the Shanghai score (n = 1613) and the Sieira (n = 461) score was, respectively, estimated by an area under the curve of 0.73 (0.67–0.79) and 0.71 (0.61–0.81). Considering Sieira score, the event rate at 10 years was significantly higher with a score of 5 (26.4%) than with a score of 0 (0.9%) or 1 (1.1%) (P Conclusions In the largest cohort of Brs patient ever described, risk scores do not allow stratifying the risk of arrhythmic event in intermediate-risk patient.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
030204 cardiovascular system & hematology
Risk Assessment
Sudden cardiac death
Electrocardiography
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
030212 general & internal medicine
Brugada Syndrome
Brugada syndrome
Framingham Risk Score
business.industry
Area under the curve
Mean age
Sudden cardiac arrest
Middle Aged
medicine.disease
Defibrillators, Implantable
Death, Sudden, Cardiac
Risk stratification
Cohort
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15229645 and 0195668X
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- European Heart Journal
- Accession number :
- edsair.doi.dedup.....e90f503bd21923863ea999bc28c3e7bf