Corresponding anaplastic lymphoma kinase–tropomyosin 3 (ALK-TPM3) fusion in a patient with a primary cutaneous anaplastic large-cell lymphoma and a Spitz nevus

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is an indolent cutaneous CD30-positive T-cell lymphoma with no signs of extracutaneous localizations at the time of diagnosis. C-ALCL is clinically characterized by single or localized, sometimes ulcerating tumors and histopathologically by diffuse sheets of large anaplastic cells.1 Spitzoid neoplasms are melanocytic tumors usually occurring in young individuals. They are characterized clinically by pigmented or spherical reddish lesions and histopathologically by spindle-shaped and epithelioid melanocytes.2 In a small proportion of patients, both diseases can be driven by or harbor rearrangements involving the anaplastic lymphoma kinase (ALK) gene.2,3