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The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
- Source :
- BMC Endocrine Disorders, BMC Endocrine Disorders, Vol 18, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- BioMed Central, 2018.
-
Abstract
- Background To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. Methods This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Subjects were randomly assigned into two groups to take either synbiotic (n = 30) or placebo (n = 30) for 12 weeks. Endocrine, inflammation and oxidative stress biomarkers were quantified at baseline and after the 12-week intervention. Results After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (changes from baseline in synbiotic group: + 19.8 ± 47.3 vs. in placebo group: + 0.5 ± 5.4 nmol/L, p = 0.01), plasma nitric oxide (NO) (changes from baseline in synbiotic group: + 5.5 ± 4.8 vs. in placebo group: + 0.3 ± 9.1 μmol/L, p = 0.006), and decreased modified Ferriman Gallwey (mF-G) scores (changes from baseline in synbiotic group: − 1.3 ± 2.5 vs. in placebo group: − 0.1 ± 0.5, p = 0.01) and serum high-sensitivity C-reactive protein (hs-CRP) (changes from baseline in synbiotic group: − 950.0 ± 2246.6 vs. in placebo group: + 335.3 ± 2466.9 ng/mL, p = 0.02). We did not observe any significant effect of synbiotic supplementation on other hormonal status and biomarkers of oxidative stress. Conclusions Overall, synbiotic supplementation for 12 weeks in PCOS women had beneficial effects on SHBG, mFG scores, hs-CRP and NO levels, but did not affect other hormonal status and biomarkers of oxidative stress. Trial registration This study was retrospectively registered in the Iranian website (www.irct.ir) for registration of clinical trials (IRCT201509115623N53), on 2015–09-27.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Placebo-controlled study
030209 endocrinology & metabolism
Endocrine System
Synbiotics
medicine.disease_cause
Placebo
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Sex hormone-binding globulin
Double-Blind Method
Diabetes mellitus
Internal medicine
Medicine
Humans
Gonadal Steroid Hormones
Polycystic ovary syndrome
Inflammation
lcsh:RC648-665
030109 nutrition & dietetics
biology
business.industry
General Medicine
medicine.disease
Prognosis
Polycystic ovary
Clinical trial
Synbiotic
Oxidative Stress
Dietary Supplements
biology.protein
Female
Hormonal status
business
Oxidative stress
Biomarkers
Hormone
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14726823 and 20150911
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Endocrine Disorders
- Accession number :
- edsair.doi.dedup.....e9097c5c7baee6c7c0f63869dadcd3bf