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Host and viral RNA-binding proteins involved in membrane targeting, replication and intercellular movement of plant RNA virus genomes

Authors :
Masanori Kaido
Tetsuro Okuno
Kiwamu Hyodo
Source :
Frontiers in Plant Science, Frontiers in Plant Science, Vol 5 (2014)
Publication Year :
2014

Abstract

Many plant viruses have positive-strand RNA [(+)RNA] as their genome. Therefore, it is not surprising that RNA-binding proteins (RBPs) play important roles during (+)RNA virus infection in host plants. Increasing evidence demonstrates that viral and host RBPs play critical roles in multiple steps of the viral life cycle, including translation and replication of viral genomic RNAs, and their intra- and intercellular movement. Although studies focusing on the RNA-binding activities of viral and host proteins, and their associations with membrane targeting, and intercellular movement of viral genomes have been limited to several viruses, these studies have provided important insights into the molecular mechanisms underlying the replication and movement of viral genomic RNAs. In this review, we briefly overview the currently defined roles of viral and host RBPs whose RNA-binding activity have been confirmed experimentally in association with their membrane targeting, and intercellular movement of plant RNA virus genomes.

Details

ISSN :
1664462X
Volume :
5
Database :
OpenAIRE
Journal :
Frontiers in plant science
Accession number :
edsair.doi.dedup.....e905e750594dc2c9c7e59589e393c9b5