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Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application
- Source :
- Journal of Veterinary Science
- Publication Year :
- 2009
- Publisher :
- The Korean Society of Veterinary Science, 2009.
-
Abstract
- Present study was undertaken to study the effect of cypermethrin on oxidative stress after chronic dermal application. The insecticide was applied dermally at 50 mg/kg body weight in different groups of Wistar rats of either sex weighing 150~200 g. Significant (p < 0.05) increase in catalase activity was observed after 30 days of exposure. However, the superoxide dismutase activity declined significantly after 60 days of exposure. The activity of glutathione peroxidase and blood glutathione levels declined significantly (p < 0.05) after 30 days of cypermethrin dermal application. However, the activity of glutathione S-transferase increased significantly (p < 0.05) in all groups after 60 days of dermal exposure. Significant increase in lipid peroxidation was observed from 30 days onwards and reached a peak after 120 days of application.
- Subjects :
- Male
Insecticides
medicine.medical_specialty
Short Communication
Administration, Cutaneous
medicine.disease_cause
Cypermethrin
Superoxide dismutase
Lipid peroxidation
chemistry.chemical_compound
Internal medicine
Pyrethrins
medicine
Animals
chronic dermal application
Rats, Wistar
chemistry.chemical_classification
General Veterinary
biology
Glutathione peroxidase
lipid peroxidation
Glutathione
Rats
Oxidative Stress
Endocrinology
chemistry
Biochemistry
cypermethrin
Catalase
biology.protein
Female
Oxidoreductases
Oxidative stress
Peroxidase
Subjects
Details
- ISSN :
- 1229845X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Science
- Accession number :
- edsair.doi.dedup.....e9037cb251fe8907052747b9cb5e0268