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Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension
- Source :
- Hepatology international, Hepatology international, Springer Internat. Publ, 2008, 2 (4), pp.457-464. ⟨10.1007/s12072-008-9070-5⟩
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- International audience; Background and aims The aims of this study were to evaluate a preventive effect on collateral venous circulation of long-term administration of propranolol in intrahepatic portal hypertensive rats. Methods Eighty-six Sprague–Dawley rats were allocated to two models of hepatic fibrosis, bile duct-ligated (BDL) induced and carbon tetrachloride (CCl4) induced. Each model was divided into two groups: one receiving placebo and the other propranolol (75 mg kg−1 d−1). Mean arterial pressure (MAP), heart rate (HR), portal pressure (PP), cardiac index (CI), vascular systemic resistance, and splenorenal shunt blood flow (SRS-BF) were measured in anesthetized rats. Results In the BDL model, no significant hemodynamic changes were observed in the propranolol group compared with the placebo group. In CCl4-induced rats, HR (390 ± 50 vs. 329 ± 51 beats/min, P = .001), CI (44 ± 11 vs. 34 ± 10 ml/min, P = .004), PP (15.4 ± 3.0 vs. 13.4 ± 1.9 mmHg, P = .045), and SRS-BF (1.4 ± 1.1 vs. 1.0 ± 1.0 ml/min, P = .047) were significantly lower in the propranolol group. Conclusions This study showed that propranolol has a significant hemodynamic effect only in the CCl4 model and suggested a model-dependent effect of propranolol.
- Subjects :
- medicine.medical_specialty
Mean arterial pressure
Portal venous pressure
[SDV]Life Sciences [q-bio]
Cardiac index
Hemodynamics
Propranolol
Placebo
03 medical and health sciences
0302 clinical medicine
Internal medicine
Heart rate
Medicine
Carbon Tetrachloride
030304 developmental biology
Collateral venous circulation
0303 health sciences
Hepatology
business.industry
Splenorenal shunt
Bile duct ligation
medicine.disease
3. Good health
Endocrinology
Cardiology
Portal hypertension
030211 gastroenterology & hepatology
Original Article
Surgery
business
Colorectal Surgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19360533 and 19360541
- Database :
- OpenAIRE
- Journal :
- Hepatology international, Hepatology international, Springer Internat. Publ, 2008, 2 (4), pp.457-464. ⟨10.1007/s12072-008-9070-5⟩
- Accession number :
- edsair.doi.dedup.....e8eba7e90c0f8231981523d882f12912