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Improving the aseptic transfer procedures in hospital pharmacies. Part B
- Source :
- European Journal of Hospital Pharmacy: Science and Practice, 28(5), 271-275. BMJ PUBLISHING GROUP, European Journal of Hospital Pharmacy, 28(5), 271-275. BMJ PUBLISHING GROUP, European Journal of Hospital Pharmacy
- Publication Year :
- 2021
- Publisher :
- BMJ PUBLISHING GROUP, 2021.
-
Abstract
- OBJECTIVES: To improve the disinfection methods for materials with a non-sterile surface to be used in aseptic handling.METHODS: The surface bioburden on ampoules (A) and injection vials (IV) is determined by contact plates and total immersion. The occurrence of spore-forming bacteria is determined by strain colouring and matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The disinfection procedures of non-sterile materials in 10 hospital pharmacies are judged by observing.RESULTS: After wiping according to local disinfection methods, the mean surface bioburden determined by contact plates in 10 hospital pharmacies is 0.36 (plastic A), 0.50 (glass A) and 0.29 colony-forming unit (cfu) (IV). The observers found great differences in accuracy of wiping and degree of wetting the sterile gauzes.After improved wiping with commercially available alcohol impregnated sterile wipes and a two-towel technique (one-step TT disinfection), the mean surface bioburden determined by contact plates is 0.03 (plastic A), 0.2 (glass A) and 0.13 cfu (IV). Further improvement can be reached by submerging A and IV in ethanol 70% followed by improved wiping (two-step TT disinfection), but still micro-organisms will remain (mean surface bioburden determined by total immersion is 0 (plastic A) and 0.3 cfu (IV); glass A not determined). Two-step TT disinfection is more labour intensive. Spilling of alcohol is another disadvantage. However, we presume one-step TT disinfection is effective enough in daily practice. Routine surface bioburden determinations have to prove this.The effectiveness of the combination of spray and wipe is not examined because we observed a quick disappearance of alcohols from vertical as well as horizontal surfaces, which shortens the contact time to far below the advised 2 min.Spore-forming bacteria disappear as quickly as other micro-organisms during disinfection by alcohols.CONCLUSION: Local disinfection procedures can be improved. Complete removal of micro-organisms from materials with a non-sterile surface, even after two-step TT disinfection, is impossible. Routine surface bioburden determinations have to prove if one-step TT disinfection is effective enough.
- Subjects :
- Disinfection methods
Pharmacies
Materials science
aseptic handling
Contact time
surface bioburden
Pulp and paper industry
030226 pharmacology & pharmacy
Vial
Ampoule
Hospitals
spore-forming bacteria
Bioburden
colony-forming unit
03 medical and health sciences
0302 clinical medicine
Daily practice
030212 general & internal medicine
Aseptic processing
General Pharmacology, Toxicology and Pharmaceutics
Hospital pharmacy
disinfection
Original Research
Subjects
Details
- Language :
- English
- ISSN :
- 20479956
- Database :
- OpenAIRE
- Journal :
- European Journal of Hospital Pharmacy: Science and Practice, 28(5), 271-275. BMJ PUBLISHING GROUP, European Journal of Hospital Pharmacy, 28(5), 271-275. BMJ PUBLISHING GROUP, European Journal of Hospital Pharmacy
- Accession number :
- edsair.doi.dedup.....e8e75d2a161ff9a93112d8c7604facde