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In vitro activity of ABT-773, telithromycin and eight other antimicrobials against erythromycin-resistant Streptococcus pneumoniae respiratory isolates of children
- Source :
- International journal of antimicrobial agents. 18(6)
- Publication Year :
- 2001
-
Abstract
- The activity of the ketolide ABT-773 against 180 erythromycin-resistant Streptococcus pneumoniae obtained from children was compared with telithromycin, azithromycin, clarithromyin, roxithromycin, clindamycin, penicillin, levofloxacin and gatifloxacin. Ketolide MICs were allor =1 mg/l, with ABT-773 being the most potent of all drugs tested. MIC(90)s for macrolides and azithromycin in mefE+ isolates were 16-32 compared with128 mg/l for ermB+ isolates. ABT-773 and telithromycin MIC(90)s for mefE+ isolates were 0.125 and 0.5, compared with 0.032 and 0.016 mg/l for ermB+ isolates and 0.5 and 1 mg/l, respectively, for isolates containing both genes. Clindamycin was active against mefE+ but not ermB+ isolates. 155 isolates were resistant to penicillin. All fluoroquinolone MICs were1 mg/l. Further studies of ketolides for treatment of paediatric S. pneumoniae infections are warranted.
- Subjects :
- Microbiology (medical)
Ketolides
Telithromycin
Drug Resistance
Erythromycin
Microbial Sensitivity Tests
Biology
medicine.disease_cause
Microbiology
Anti-Infective Agents
Drug Resistance, Multiple, Bacterial
Streptococcus pneumoniae
polycyclic compounds
medicine
Humans
Pharmacology (medical)
Child
Ketolide
Antibacterial agent
Dose-Response Relationship, Drug
Roxithromycin
General Medicine
Gatifloxacin
Anti-Bacterial Agents
Penicillin
Infectious Diseases
Macrolides
medicine.drug
Fluoroquinolones
Subjects
Details
- ISSN :
- 09248579
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of antimicrobial agents
- Accession number :
- edsair.doi.dedup.....e8e6c29a0084402178e786659aeaca71