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Additive effect of cerebral atrophy on cognition in dementia-free elderly with cerebrovascular disease
- Source :
- Stroke and Vascular Neurology, 4(3), 135-140. BMJ Publishing Group, Stroke and Vascular Neurology
- Publication Year :
- 2019
-
Abstract
- ObjectiveTo explore the additive effect of neurodegenerative diseases, measured by atrophy, on neurocognitive function in Asian dementia-free elderly with cerebrovascular disease (CeVD).MethodsThe present study employed a cross-sectional design and was conducted between 2010 and 2015 among community-dwelling elderly participants recruited into the study. Eligible participants were evaluated with an extensive neuropsychological battery and neuroimaging. The weighted CeVD burden scale comprising markers of both small- and large-vessel diseases was applied, with a score of ≥2, indicating significant CeVD burden. Cortical atrophy (CA) and medial temporal atrophy (MTA) were graded using the global cortical atrophy scale and Schelten’s scale, respectively. Global and domain-specific (attention, executive function, language, visuomotor speed, visuoconstruction, visual memory, and verbal memory) neurocognitive performance was measured using a locally validated neuropsychological battery (Vascular Dementia Battery, VDB).ResultsA total of 819 dementia-free participants were included in the analysis. Among none-mild CeVD subjects, there was no significant difference in the global cognitive performance across atrophy groups (no atrophy, CA, and CA+MTA). However, in moderate-severe CeVD subjects, CA+MTA showed significantly worse global cognitive performance compared with those with CA alone (mean difference=−0.35, 95% CI −0.60 to −0.11, p=0.002) and those without atrophy (mean difference=−0.46, 95% CI −0.74 to −0.19, pConclusions and relevanceAtrophy and moderate-severe CeVD burden showed an additive effect on global and domain-specific cognitive performance. This study highlights the importance of investigating the mechanisms of clinico-pathological interactions between neurodegenerative processes and vascular damage, particularly in the pre-dementia stage.
- Subjects :
- Male
medicine.medical_specialty
Neuroimaging
Neuropsychological Tests
Severity of Illness Index
03 medical and health sciences
Cognition
0302 clinical medicine
Atrophy
Visual memory
Risk Factors
Internal medicine
medicine
Humans
Dementia
Cognitive Dysfunction
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
Vascular dementia
Aged
Aged, 80 and over
Cerebral atrophy
Singapore
business.industry
Brain
Middle Aged
medicine.disease
Magnetic Resonance Imaging
cerebrovascular disease
Cerebrovascular Disorders
Cross-Sectional Studies
Cardiology
Original Article
Female
Neurology (clinical)
Verbal memory
Cardiology and Cardiovascular Medicine
business
Neurocognitive
030217 neurology & neurosurgery
dementia
Subjects
Details
- ISSN :
- 20598688
- Database :
- OpenAIRE
- Journal :
- Stroke and Vascular Neurology, 4(3), 135-140. BMJ Publishing Group, Stroke and Vascular Neurology
- Accession number :
- edsair.doi.dedup.....e8e0ddd53d58332c57464a0067be2890