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Protective Effect of Irbesartan an Angiotensin (AT1) Receptor Antagonist in Unpredictable Chronic Mild Stress Induced Depression in Mice
- Source :
- Drug Research. 67:59-64
- Publication Year :
- 2016
- Publisher :
- Georg Thieme Verlag KG, 2016.
-
Abstract
- Objective: Oxidative stress and alternation of renin-angiotensin system has been implicated in the pathophysiology of various cardio vascular, endocrine including mood and anxiety disorders. The present study evaluated the role of irbesartan in stress induced different models of depression. Materials and method: Mice were treated with irbesartan (40 mg/kg), fluoxetine (25 mg/kg) alone in combination orally. Drugs treatment started after 2 weeks from the beginning of the unpredictable mild stress (UCMS) protocol. Behavioural tests were performed on week 6, at least 24 h after the last treatment. Modified forced swim test (MFST), tail suspension test (TST) and open field test (OFT) were used followed by antioxidant markers and 5-HT levels determination. Result: Irbesartan increased swimming, climbing and decreased immobility times in MFST, decrease immobility time in TST. Irbesartan also increased no. of field crossings; rearings and also increased time spent in the centre of OFT. Thus, antidepressant like activity in UCMS mice was observed. Combination of irbesartan with fluoxetine showed potentiating effect of behavioural parameters in all animal models. Combination groups also showed antioxidant effects and elevated the 5-HT levels in UCMS mice. Conclusion: Chronic administration of Irbesartan exerted antidepressant like effect, reduced oxidative stress and elevated brain 5-HT levels.
- Subjects :
- Male
0301 basic medicine
Serotonin
medicine.medical_specialty
Tetrazoles
Motor Activity
Pharmacology
Protective Agents
medicine.disease_cause
Antioxidants
Open field
Mice
03 medical and health sciences
0302 clinical medicine
Irbesartan
Fluoxetine
Internal medicine
Drug Discovery
medicine
Animals
Angiotensin II receptor type 1
Depression
business.industry
Biphenyl Compounds
Antagonist
Brain
Drug Synergism
Immobility Response, Tonic
General Medicine
Antidepressive Agents
Tail suspension test
Oxidative Stress
030104 developmental biology
Endocrinology
Drug Therapy, Combination
business
Angiotensin II Type 1 Receptor Blockers
Stress, Psychological
030217 neurology & neurosurgery
Oxidative stress
medicine.drug
Behavioural despair test
Subjects
Details
- ISSN :
- 21949387 and 21949379
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Drug Research
- Accession number :
- edsair.doi.dedup.....e8d788ef1bcdf3a77dbf741445b97cd5