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A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis
- Source :
- Allergy and Asthma Proceedings. 34:542-550
- Publication Year :
- 2013
- Publisher :
- Oceanside Publications Inc., 2013.
-
Abstract
- Patients' preference and satisfaction with their nasal allergy medications may be influenced by their sensory attributes. This study evaluates patient preference and satisfaction with ciclesonide hydrofluoroalkane nasal aerosol (CIC-HFA) compared with mometasone furoate aqueous nasal spray (MFNS). Symptomatic subjects with perennial allergic rhinitis (PAR) were randomized to CIC-HFA at 74 micrograms or MFNS at 200 micrograms q.d. in an open-label, two-period, crossover study. Subject preference was recorded as total preference score (TPS; average of 17 individual preference items) at the end of treatment period 2, and satisfaction was assessed with a 76-item, self-administered instrument at baseline and at the end of each 2-week treatment period. The primary assessments were TPS and regimen attributes composite satisfaction score composed of two of nine satisfaction subscales: sensory impact (including medication running out of the nose, medication running down the throat, and impact on smell and taste) and regimen management (comprised of issues relating to dosing and ability to remember to take medication). Two hundred ninety-four subjects completed the study. A total of 68.1% of subjects preferred CIC-HFA (p < 0.0001 versus MFNS), with a mean TPS of 68.3 versus 31.7 for the MFNS group. The regimen attributes composite satisfaction score significantly (p < 0.0001 for each treatment period) favored CIC-HFA versus MFNS at the end of treatment period 1 (85.5 vs 77.6) and treatment period 2 (83.0 versus 73.5), respectively. In this study, subjects reported higher preference for and satisfaction with CIC-HFA compared with MFNS, suggesting significant differences in patient perception of attributes in favor of CIC-HFA. Clinical trial registration URL and registration number: www.clinicaltrials.gov/ct2/show/NCT01401465.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Rhinitis, Allergic, Perennial
medicine.medical_treatment
Mometasone furoate
Ciclesonide
law.invention
Young Adult
chemistry.chemical_compound
Patient satisfaction
Randomized controlled trial
Pregnenediones
law
Surveys and Questionnaires
Internal medicine
Humans
Immunology and Allergy
Medicine
Drug Dosage Calculations
Pregnadienediols
Administration, Intranasal
Nose
Aerosols
Cross-Over Studies
business.industry
Patient Preference
Nasal Sprays
General Medicine
Middle Aged
Crossover study
Regimen
Treatment Outcome
medicine.anatomical_structure
chemistry
Nasal spray
Patient Satisfaction
Anesthesia
Female
business
Mometasone Furoate
medicine.drug
Subjects
Details
- ISSN :
- 10885412
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Allergy and Asthma Proceedings
- Accession number :
- edsair.doi.dedup.....e8ce19f3746f089f0c0c417af241b8a6