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The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging
- Source :
- Europe PubMed Central, Journal of Alzheimer's Disease, Vol. 40, No 4 (2014) pp. 941-52, Journal of Alzheimer's disease (2014). doi:10.3233/JAD-132666, info:cnr-pdr/source/autori:Cavedo E, Redolfi A, Angeloni F, Babiloni C, Lizio R, Chiapparini L, Bruzzone MG, Aquino D, Sabatini U, Alesiani M, Cherubini A, Salvatore E, Soricelli A, Vernieri F, Scrascia F, Sinforiani E, Chiarati P, Bastianello S, Montella P, Corbo D, Tedeschi G, Marino S, Baglieri A, De Salvo S, Carducci F, Quattrocchi CC, Cobelli M, Frisoni GB./titolo:The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging./doi:10.3233%2FJAD-132666/rivista:Journal of Alzheimer's disease/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume
- Publication Year :
- 2014
-
Abstract
- Background: The North American Alzheimer's Disease Neuroimaging Initiative (NA-ADNI) was the first program to develop standardized procedures for Alzheimer's disease (AD) imaging biomarker collection. Objective: We describe the validation of acquisition and processing of structural magnetic resonance imaging (MRI) in different Italian academic AD clinics following NA-ADNI procedures. Methods: 373 patients with subjective memory impairment (n = 12), mild cognitive impairment (n = 92), Alzheimer's dementia (n = 253), and frontotemporal dementia (n = 16) were enrolled in 9 Italian centers. Also included were 22 cognitively healthy elderly controls. MRI site qualification and MP-RAGE quality assessment was applied following the NA-ADNI procedures. Indices of validity were: (i) AN-ADNI phantom's signal-to-noise and contrast-to-noise ratio, (ii) proportion of images passing quality control, (iii) comparability of automated intracranial volume (ICV) estimates across scanners, and (iv) known-group validity of manual hippocampal volumetry. Results: Results on Phantom and Volunteers scans showed that I-ADNI acquisition parameters were comparable with those one of the ranked-A ADNI scans. Eighty-seven percent of I-ADNI MPRAGE images were ranked of high quality in comparison of 69% of NA-ADNI. ICV showed homogeneous variances across scanners except for Siemens scanners at 3.0 Tesla (p = 0.039). A significant difference in hippocampal volume was found between AD and controls on 1.5 Tesla scans (p < 0.001), confirming known group validity test. Conclusion: This study has provided standardization of MRI acquisition and imaging marker collection across different Italian clinical units and equipment. This is a mandatory step to the implementation of imaging biomarkers in clinical routine for early and differential diagnosis.
- Subjects :
- Male
Imaging biomarker
hippocampus
intracranial volume
standardized operating procedures
Neuropsychological Tests
Structural magnetic resonance imaging
ddc:616.89
mild cognitive impairment
Neuroimaging
Alzheimer Disease
Intracranial volume
mental disorders
Image Processing, Computer-Assisted
medicine
Humans
Analysis of Variance
medicine.diagnostic_test
business.industry
General Neuroscience
alzheimer's disease
magnetic resonance imaging
Brain
Reproducibility of Results
Magnetic resonance imaging
General Medicine
Magnetic Resonance Imaging
Mr imaging
Psychiatry and Mental health
Clinical Psychology
Italy
Female
Geriatrics and Gerontology
business
Neuroscience
Alzheimer's Disease Neuroimaging Initiative
Subjects
Details
- ISSN :
- 13872877
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central, Journal of Alzheimer's Disease, Vol. 40, No 4 (2014) pp. 941-52, Journal of Alzheimer's disease (2014). doi:10.3233/JAD-132666, info:cnr-pdr/source/autori:Cavedo E, Redolfi A, Angeloni F, Babiloni C, Lizio R, Chiapparini L, Bruzzone MG, Aquino D, Sabatini U, Alesiani M, Cherubini A, Salvatore E, Soricelli A, Vernieri F, Scrascia F, Sinforiani E, Chiarati P, Bastianello S, Montella P, Corbo D, Tedeschi G, Marino S, Baglieri A, De Salvo S, Carducci F, Quattrocchi CC, Cobelli M, Frisoni GB./titolo:The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging./doi:10.3233%2FJAD-132666/rivista:Journal of Alzheimer's disease/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume
- Accession number :
- edsair.doi.dedup.....e8c90056a10e6bde2757c59e80753728