Back to Search
Start Over
Mapping the Epigenetic Basis of Complex Traits
- Source :
- Science, Science, 2014, 343 (6175), pp.1145-1148. ⟨10.1126/science.1248127⟩, Science, American Association for the Advancement of Science, 2014, 343 (6175), pp.1145-1148. ⟨10.1126/science.1248127⟩, Science; Vol 343, Science, 343(6175), 1145-1148. AMER ASSOC ADVANCEMENT SCIENCE
- Publication Year :
- 2014
- Publisher :
- AMER ASSOC ADVANCEMENT SCIENCE, 2014.
-
Abstract
- Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic quantitative trait loci (QTL epi ), accounting for 60 to 90% of the heritability for two complex traits, flowering time and primary root length. These QTL epi are reproducible and can be subjected to artificial selection. Many of the experimentally induced DMRs are also variable in natural populations of this species and may thus provide an epigenetic basis for Darwinian evolution independently of DNA sequence changes.
- Subjects :
- 0106 biological sciences
[SDV]Life Sciences [q-bio]
Quantitative Trait Loci
Population
Arabidopsis
Population genetics
Biology
Quantitative trait locus
01 natural sciences
Genome
Epigenesis, Genetic
03 medical and health sciences
Gene Expression Regulation, Plant
PLANTS
Epigenetics
Selection, Genetic
education
DNA METHYLATION
030304 developmental biology
Genetics
0303 health sciences
education.field_of_study
Multidisciplinary
ANIMALS
Chromosome Mapping
Heritability
Differentially methylated regions
DNA methylation
ARABIDOPSIS-THALIANA
PATTERNS
010606 plant biology & botany
Subjects
Details
- Language :
- English
- ISSN :
- 10959203 and 00368075
- Volume :
- 343
- Issue :
- 6175
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....e8bf87c4fe73fab7a61f926dd4a65288