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Effects of repeated low dose administration and withdrawal of haloperidol on sexual behaviour of male rats
- Source :
- Scopus-Elsevier
- Publication Year :
- 1999
-
Abstract
- Neuroleptics are known to cause anhedonia and attenuate sexual behaviour at therapeutic doses in humans. These effects are assumed to result from the dopamine antagonism of the drugs. It has been observed that a mixed dopamine D1/D2 antagonist, haloperidol, may cause a reduction in the number of intromissions required to achieve ejaculation. On the other hand, dopamine antagonists are considered unable to modify sexual behaviour once the copulatory sequence is initiated. In this study, male rats received low doses of haloperidol (30 or 60 microg/kg) before the investigation of sexual behaviour in five consecutive days and the mating test was repeated after withdrawal periods of four and five days. Haloperidol dose-dependently reduced intromission frequency, and this effect was maintained for four days after withdrawal. Ejaculation latency was reduced in all groups, including controls. The results indicate that at low doses haloperidol dose-dependently reduces intromission frequency, and the effect of a repeated dosage may persist several days after cessation of medication.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Ejaculation
Health, Toxicology and Mutagenesis
Toxicology
Dopamine
Internal medicine
Copulation
medicine
Haloperidol
Animals
Rats, Wistar
Pharmacology
Behavior, Animal
Dose-Response Relationship, Drug
business.industry
Low dose
Dopamine antagonist
Anhedonia
Rats
Dose–response relationship
Endocrinology
Toxicity
Dopamine Antagonists
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 09019928
- Volume :
- 84
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pharmacologytoxicology
- Accession number :
- edsair.doi.dedup.....e8b8d043aa4bc61b48f18d907fd81b9c