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Effects of ranitidine on the enzyme cholinesterase and the rat anococcygeus muscle
- Source :
- Agents and actions. 21(1-2)
- Publication Year :
- 1987
-
Abstract
- Ranitidine in lower doses, (100 ng and 1 microgram) accelerated the rate of reaction of the enzyme acetylcholinesterase with the substrate acetylthiocholine. However, in higher doses (10 micrograms and 100 micrograms) it inhibited the enzyme activity. In rat anococcygeus muscle preparation, the responses to acetylcholine were significantly inhibited in lower doses whereas in higher doses there was a dose-dependent potentiation of the responses to acetylcholine by ranitidine. The responses to carbachol were however, not affected by ranitidine in the same preparation. Our data suggest cholinomimetic as well as cholinolytic activity of ranitidine.
- Subjects :
- Male
medicine.medical_specialty
Physostigmine
Carbachol
Immunology
Biology
Toxicology
Ranitidine
chemistry.chemical_compound
Internal medicine
medicine
Animals
Pharmacology (medical)
Cholinesterase
Pharmacology
Dose-Response Relationship, Drug
Muscles
Rats, Inbred Strains
Acetylcholinesterase
Enzyme assay
Acetylcholine
Rats
Endocrinology
chemistry
Acetylthiocholine
biology.protein
Cholinesterase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 00654299
- Volume :
- 21
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Agents and actions
- Accession number :
- edsair.doi.dedup.....e8b8c78ba1f67aab827b4eddae9fa544