Back to Search
Start Over
Antioxidant activity ofGanoderma lucidum in acute ethanol-induced heart toxicity
- Source :
- Phytotherapy Research. 18:1024-1026
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- The hot water extract of the mushroom Ganoderma lucidum was shown to have antioxidative effect against heart toxicity. Investigations into the mechanisms of action, level of lipid peroxidation level in vivo, and superoxide scavenging activity were also conducted. The mice were divided into six groups with ten animals in each group. Ganoderma lucidum, at doses of 10, 25 and 50 mg/kg (p.o.) was administered. Superoxide anions were assayed by UV spectrophotometer using the cytochrome C reduction method. The results of this study showed that Ganoderma lucidum exhibited a dose-dependent antioxidative effect on lipid peroxidation and superoxide scavenging activity in mouse heart homogenate. Additionally, this result indicated that heart damage induced by ethanol shows a higher malonic dialdehyde level compared with heart homogenate treated with Ganoderma lucidum. It is concluded that the antioxidative activity may therefore contribute to the cardioprotective effect of Ganoderma lucidum, and may therefore protect the heart from superoxide induced damage.
- Subjects :
- Male
Cardiotonic Agents
Reishi
Antioxidant
Heart Diseases
Ganoderma
medicine.medical_treatment
Administration, Oral
Pharmacology
Pharmacognosy
Thiobarbituric Acid Reactive Substances
Antioxidants
law.invention
Lipid peroxidation
Mice
chemistry.chemical_compound
Superoxides
law
medicine
Animals
Mice, Inbred ICR
Ethanol
biology
Plant Extracts
Chemistry
Superoxide
Cytochrome c
Free Radical Scavengers
biology.organism_classification
Biochemistry
Toxicity
biology.protein
Lipid Peroxidation
Phytotherapy
Subjects
Details
- ISSN :
- 10991573 and 0951418X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Phytotherapy Research
- Accession number :
- edsair.doi.dedup.....e8b2d7b2dc239ef8d9b8303c6edec566